5-(BROMOMETHYL)THIOPHENE-2-CARBONITRILE
- Product Name
- 5-(BROMOMETHYL)THIOPHENE-2-CARBONITRILE
- CAS No.
- 134135-41-4
- Chemical Name
- 5-(BROMOMETHYL)THIOPHENE-2-CARBONITRILE
- Synonyms
- 5-(BROMOMETHYL)THIOPHENE-2-CARBONITRILE;5-(bromomethyl)-2-Thiophenecarbonitrile;2-Thiophenecarbonitrile, 5-(bromomethyl)-
- CBNumber
- CB3208944
- Molecular Formula
- C6H4BrNS
- Formula Weight
- 202.07
- MOL File
- 134135-41-4.mol
5-(BROMOMETHYL)THIOPHENE-2-CARBONITRILE Property
- Boiling point:
- 276.9±25.0 °C(Predicted)
- Density
- 1.68±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H332Harmful if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B686608
- Product name
- 5-(Bromomethyl)thiophene-2-carbonitrile
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B686608
- Product name
- 5-(Bromomethyl)thiophene-2-carbonitrile
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB144416
- Product name
- 5-(Bromomethyl)thiophene-2-carbonitrile
- Packaging
- 250mg
- Price
- $112.5
- Updated
- 2021/12/16
- Product number
- FB144416
- Product name
- 5-(Bromomethyl)thiophene-2-carbonitrile
- Packaging
- 100mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- Z4102
- Product name
- 5-(Bromomethyl)thiophene-2-carbonitrile
- Packaging
- 1g
- Price
- $223
- Updated
- 2021/12/16
5-(BROMOMETHYL)THIOPHENE-2-CARBONITRILE Chemical Properties,Usage,Production
Synthesis
72835-25-7
134135-41-4
Using 5-methylthiophene-2-carbonitrile (9.9 g, 80.5 mmol) as starting material, benzoyl peroxide (0.23 g, 0.95 mmol) and N-bromosuccinimide (15 g, 84.3 mmol) were added in carbon tetrachloride (200 mL), and the reaction was heated and refluxed for 6 hours. Upon completion of the reaction, the resulting suspension was filtered and the filtrate was diluted with dichloromethane (400 mL) and subsequently washed with saturated sodium bicarbonate solution and dried with magnesium sulfate. The dried solution was concentrated under vacuum to give the crude product. The crude product was purified by column chromatography (eluent: ethyl acetate/hexane, 1:4) to afford 5-bromomethylthiophene-2-carbonitrile as a yellow oil (14.0 g, 86% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 7.50 (d, 1H), 7.13 (d, 1H), 4.68 (s, 2H).FAB MS showed the molecular ion peak as 203 [M + 1]+.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 5, p. 743 - 748
[2] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 13, p. 1683 - 1686
[3] Journal of Medicinal Chemistry, 2003, vol. 46, # 17, p. 3612 - 3622
[4] Patent: EP1140918, 2004, B1. Location in patent: Page 14
[5] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 7, p. 1017 - 1022
5-(BROMOMETHYL)THIOPHENE-2-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
5-(BROMOMETHYL)THIOPHENE-2-CARBONITRILE Suppliers
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 15121041756
- xingui2022@126.com
- Country
- China
- ProdList
- 9979
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 021-34979681; 17701870669
- Fax
- 021-34979681
- 41513101@qq.com
- Country
- China
- ProdList
- 1785
- Advantage
- 55
- Tel
- 13162380607
- Fax
- QQ:1696175688
- 1696175688@qq.com
- Country
- China
- ProdList
- 817
- Advantage
- 55
- Tel
- 0371-53765687 18937137882
- Fax
- QQ:2885373884
- 2853979813@qq.com
- Country
- China
- ProdList
- 7992
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 18701958033
- Fax
- 021-60441077
- shzxchem@163.com
- Country
- China
- ProdList
- 649
- Advantage
- 58