ChemicalBook > CAS DataBase List > 4-Boc-2-(hydroxymethyl)homomorpholine
4-Boc-2-(hydroxymethyl)homomorpholine
- Product Name
- 4-Boc-2-(hydroxymethyl)homomorpholine
- CAS No.
- 1174020-52-0
- Chemical Name
- 4-Boc-2-(hydroxymethyl)homomorpholine
- Synonyms
- tert-Butyl 2-(hydroxymethyl);-1,4-oxazepane-4-carboxylate;4-Boc-1,4-oxazepan-2-methanol;4-Boc-2-hydroxymethyl-1,4-oxazepane;4-Boc-2-(hydroxymethyl)homomorpholine;tert-Butyl 2-(hydroxyMethyl)-1,4-oxazepane-4-carboxylate;1,4-Oxazepine-4(5H)-carboxylic acid, tetrahydro-2-(hydroxymethyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB32534452
- Molecular Formula
- C11H21NO4
- Formula Weight
- 231.29
- MOL File
- 1174020-52-0.mol
More
Less
4-Boc-2-(hydroxymethyl)homomorpholine Property
- Boiling point:
- 337.8±27.0 °C(Predicted)
- Density
- 1.090±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.36±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
More
Less
N-Bromosuccinimide Price
AK Scientific
- Product number
- 2839AA
- Product name
- tert-Butyl2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 126724
- Product name
- tert-Butyl2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $316
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- AGR0000199
- Product name
- 4-BOC-2-(HYDROXYMETHYL)HOMOMORPHOLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $321.3
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 126724
- Product name
- tert-Butyl2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $1098
- Updated
- 2021/12/16
Ambeed
- Product number
- A156935
- Product name
- tert-Butyl2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate
- Purity
- 98+%
- Packaging
- 250mg
- Price
- $53
- Updated
- 2021/12/16
More
Less
4-Boc-2-(hydroxymethyl)homomorpholine Chemical Properties,Usage,Production
Synthesis
24424-99-5
1207254-23-6
1174020-52-0
Step-4: Synthesis of tert-butyl 2-(hydroxymethyl)-1,4-oxoazepane-4-carboxylate To a dichloromethane solution of (1,4-oxoazepan-2-yl)methanol (550 mg, 4.2 mmol) was added triethylamine (1.2 mL, 8.4 mmol) and di-tert-butyl dicarbonate (1.1 equiv., 1 mL, 4.61 mmol) sequentially at 0°C. The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction was quenched with saturated NaHCO3 solution and then extracted with ethyl acetate. The organic layer was washed sequentially with water and brine, dried over anhydrous Na2SO4 and concentrated to give the target product tert-butyl 2-(hydroxymethyl)-1,4-oxoazepane-4-carboxylate (800 mg, 82.6% yield). 1H NMR (400 MHz, DMSO-d6) δ: 4.68 (m, 1H), 3.95 (m, 1H), 3.70 (m, 1H), 3.54-2.98 (m, 6H), 1.74 (m, 2H), 1.46 (m, 1H), 1.39 (s, 4H).
References
[1] Patent: US2010/168080, 2010, A1. Location in patent: Page/Page column 89
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 6, p. 2227 - 2244
4-Boc-2-(hydroxymethyl)homomorpholine Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
4-Boc-2-(hydroxymethyl)homomorpholine Suppliers
- Tel
- 513-85982855 18921614129
- Fax
- 051385915507
- sales@xianxingpharm.com
- Country
- China
- ProdList
- 2986
- Advantage
- 61
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 13817485796
- Fax
- QQ:895624079
- tim@wisacheampharm.com
- Country
- China
- ProdList
- 3592
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28785
- Advantage
- 58
- Tel
- 025-58851090 15955137747
- Fax
- (6)02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15949
- Advantage
- 58
- Tel
- 021-18017654 18017654809
- Fax
- 2271705492
- sales@vigorchem.cn
- Country
- China
- ProdList
- 958
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12884
- Advantage
- 58
- Tel
- 15990591583
- Fax
- qq: 1050376806 mailbox : sales@nbpharmabridge.com
- Country
- China
- ProdList
- 6109
- Advantage
- 58
- Tel
- 18012778619
- 3394205705@qq.com
- Country
- China
- ProdList
- 9847
- Advantage
- 58
- Tel
- nanfengdrug@163.com; 18616377689
- nanfengdrug@163.com
- Country
- China
- ProdList
- 20009
- Advantage
- 58
- Tel
- 0371-0371-53736046 13393710386
- Fax
- QQ:2853979814
- 2853979814@qq.com
- Country
- China
- ProdList
- 9947
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44119
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 0531-88924771 15614660963
- elsa.hang@strongerscience.com
- Country
- China
- ProdList
- 10623
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62220
- Advantage
- 58
- Tel
- 13588473046
- jiaxingshidy@163.com
- Country
- China
- ProdList
- 7865
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58
- Tel
- 13761144602
- 3896578657@qq.com
- Country
- China
- ProdList
- 4483
- Advantage
- 58
- Tel
- 17525889330
- 17525889330@163.com
- Country
- China
- ProdList
- 7762
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58