4-Boc-2-(hydroxymethyl)homomorpholine

Product Name: 4-Boc-2-(hydroxymethyl)homomorpholine
CAS No.: 1174020-52-0
Chemical Name: 4-Boc-2-(hydroxymethyl)homomorpholine
Synonyms: tert-Butyl 2-(hydroxymethyl);-1,4-oxazepane-4-carboxylate;4-Boc-1,4-oxazepan-2-methanol;4-Boc-2-hydroxymethyl-1,4-oxazepane;4-Boc-2-(hydroxymethyl)homomorpholine;tert-Butyl 2-(hydroxyMethyl)-1,4-oxazepane-4-carboxylate;1,4-Oxazepine-4(5H)-carboxylic acid, tetrahydro-2-(hydroxymethyl)-, 1,1-dimethylethyl ester
CBNumber: CB32534452
Molecular Formula: C11H21NO4
Formula Weight: 231.29
MOL File: 1174020-52-0.mol

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4-Boc-2-(hydroxymethyl)homomorpholine Property

Boiling point:: 337.8±27.0 °C(Predicted)
Density: 1.090±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.36±0.10(Predicted)
Appearance: Colorless to light yellow Liquid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 2839AA
Product name: tert-Butyl2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate
Packaging: 250mg
Price: $130
Updated: 2021/12/16

Matrix Scientific

Product number: 126724
Product name: tert-Butyl2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate
Purity: >95%
Packaging: 1g
Price: $316
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AGR0000199
Product name: 4-BOC-2-(HYDROXYMETHYL)HOMOMORPHOLINE
Purity: 95.00%
Packaging: 1G
Price: $321.3
Updated: 2021/12/16

Matrix Scientific

Product number: 126724
Product name: tert-Butyl2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate
Purity: >95%
Packaging: 5g
Price: $1098
Updated: 2021/12/16

Chemenu

Product number: CM121783
Product name: tert-Butyl2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate
Purity: 95%
Packaging: 5g
Price: $393
Updated: 2021/12/16

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4-Boc-2-(hydroxymethyl)homomorpholine Chemical Properties,Usage,Production

Synthesis

24424-99-5

1207254-23-6

1174020-52-0

Step-4: Synthesis of tert-butyl 2-(hydroxymethyl)-1,4-oxoazepane-4-carboxylate To a dichloromethane solution of (1,4-oxoazepan-2-yl)methanol (550 mg, 4.2 mmol) was added triethylamine (1.2 mL, 8.4 mmol) and di-tert-butyl dicarbonate (1.1 equiv., 1 mL, 4.61 mmol) sequentially at 0°C. The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction was quenched with saturated NaHCO3 solution and then extracted with ethyl acetate. The organic layer was washed sequentially with water and brine, dried over anhydrous Na2SO4 and concentrated to give the target product tert-butyl 2-(hydroxymethyl)-1,4-oxoazepane-4-carboxylate (800 mg, 82.6% yield). 1H NMR (400 MHz, DMSO-d6) δ: 4.68 (m, 1H), 3.95 (m, 1H), 3.70 (m, 1H), 3.54-2.98 (m, 6H), 1.74 (m, 2H), 1.46 (m, 1H), 1.39 (s, 4H).

References

[1] Patent: US2010/168080, 2010, A1. Location in patent: Page/Page column 89
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 6, p. 2227 - 2244

4-Boc-2-(hydroxymethyl)homomorpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Boc-2-(hydroxymethyl)homomorpholine Suppliers

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1174020-52-0, 4-Boc-2-(hydroxymethyl)homomorpholineRelated Search:

4-Boc-2-(hydroxymethyl)homomorpholine

tert-Butyl 2-(hydroxyMethyl)-1,4-oxazepane-4-carboxylate

-1,4-oxazepane-4-carboxylate

tert-Butyl 2-(hydroxymethyl)

1,4-Oxazepine-4(5H)-carboxylic acid, tetrahydro-2-(hydroxymethyl)-, 1,1-dimethylethyl ester

4-Boc-1,4-oxazepan-2-methanol

4-Boc-2-hydroxymethyl-1,4-oxazepane

1174020-52-0