ChemicalBook > CAS DataBase List > Tertiapin Q

Tertiapin Q

Product Name: Tertiapin Q
CAS No.: 910044-56-3
Chemical Name: Tertiapin Q
Synonyms: Teriapin Q;Tertiapin-Q TFA;L-Lysinamide, L-alanyl-L-leucyl-L-cysteinyl-L-asparaginyl-L-cysteinyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-isoleucyl-L-prolyl-L-histidyl-L-glutaminyl-L-cysteinyl-L-tryptophyl-L-lysyl-L-lysyl-L-cysteinylglycyl-L-lysyl-, cyclic (3→14),(5→18)-bis(disulfide)
CBNumber: CB32589649
Molecular Formula: C106H175N35O24S4
Formula Weight: 2452.01
MOL File: 910044-56-3.mol

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Tertiapin Q Property

Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: -20°C
form: Solid
color: White to off-white
Water Solubility: Soluble in water (2mg/ml)
Sequence: Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2 (Disulfide bridge: Cys3-Cys14, Cys5-Cys18)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T1567
Product name: Tertiapin-Q trifluoroacetate salt
Purity: ≥97% (HPLC)
Packaging: 0.5MG
Price: $749
Updated: 2025/07/31

ChemScene

Product number: CS-0029213
Product name: Tertiapin-Q
Purity: 97.46%
Packaging: 5mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0029213
Product name: Tertiapin-Q
Purity: 97.46%
Packaging: 1mg
Price: $330
Updated: 2021/12/16

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Tertiapin Q Chemical Properties,Usage,Production

Uses

Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1).

Biochem/physiol Actions

Blocks the GIRK1/4 and ROMK1 members of the inward-rectifier K+ channel family.

in vivo

Tertiapin-Q is a muscarinic acetylcholine receptor-operated K⁺ current (I_K,Ach) blocker. After the cessation of rapid atrial pacing, the atrial effective refractory period (AERP) is unchanged during the experimental period in the rapid atrial pacing (RAP) rabbits (n=6). Bepridil (1 mg/kg, n=5 for each group), Amiodarone (10 mg/kg, n=5 for each group), Vernakalant (3 mg/kg, n=5 for each group), Ranolazine (10 mg/kg, n=6 for each group) or Tertiapin-Q (0.03 mg/kg, n=5 for each group) on the AERP in the control and RAP rabbits. Tertiapin-Q significantly prolongs the AERP at each pacing cycle length both in the control and RAP rabbits. The extents of prolonging effect of Tertiapin-Q on the AERP in the RAP rabbits are greater than those in the control animals^[3].

storage

-20°C (desiccate)

References

[1] Picton LD, et al. Mechanisms underlying the endogenous dopaminergic inhibition of spinal locomotor circuit function in Xenopus tadpoles. Sci Rep. 2016 Oct 20;6:35749. DOI:10.1038/srep35749
[2] Günther T, et al. Research Resource: Real-Time Analysis of Somatostatin and Dopamine Receptor Signaling in Pituitary Cells Using a Fluorescence-Based Membrane Potential Assay. Mol Endocrinol. 2016 Apr;30(4):479-90. DOI:10.1210/me.2015-1241
[3] Chiba T, et al. Influences of rapid pacing-induced electrical remodeling on pharmacological manipulation of the atrial refractoriness in rabbits. J Pharmacol Sci. 2016 Mar;130(3):170-6. DOI:10.1016/j.jphs.2016.02.007

Tertiapin Q Preparation Products And Raw materials

Raw materials

Preparation Products

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910044-56-3, Tertiapin QRelated Search:

Oligopeptide-91 Pentapeptide-24 Myristoyl Hexapeptide-14 Decapeptide-17 Hepcidin 1 (Mouse) (Lys(Me)2)-Histone H3 (1-21)-Gly-Gly-Lys(biotinyl) Decapeptide Histone H3 (1-20) Heptapeptide-16 Hexapeptide-52

Teriapin Q

L-Lysinamide, L-alanyl-L-leucyl-L-cysteinyl-L-asparaginyl-L-cysteinyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-isoleucyl-L-prolyl-L-histidyl-L-glutaminyl-L-cysteinyl-L-tryptophyl-L-lysyl-L-lysyl-L-cysteinylglycyl-L-lysyl-, cyclic (3→14),(5→18)-bis(disulfide)

Tertiapin-Q TFA

910044-56-3