Tertiapin Q
- Product Name
- Tertiapin Q
- CAS No.
- 910044-56-3
- Chemical Name
- Tertiapin Q
- Synonyms
- Teriapin Q;Tertiapin-Q TFA;L-Lysinamide, L-alanyl-L-leucyl-L-cysteinyl-L-asparaginyl-L-cysteinyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-isoleucyl-L-prolyl-L-histidyl-L-glutaminyl-L-cysteinyl-L-tryptophyl-L-lysyl-L-lysyl-L-cysteinylglycyl-L-lysyl-, cyclic (3→14),(5→18)-bis(disulfide)
- CBNumber
- CB32589649
- Molecular Formula
- C106H175N35O24S4
- Formula Weight
- 2452.01
- MOL File
- 910044-56-3.mol
Tertiapin Q Property
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- form
- Solid
- color
- White to off-white
- Water Solubility
- Soluble in water (2mg/ml)
- Sequence
- Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2 (Disulfide bridge: Cys3-Cys14, Cys5-Cys18)
N-Bromosuccinimide Price
- Product number
- T1567
- Product name
- Tertiapin-Q trifluoroacetate salt
- Purity
- ≥97% (HPLC)
- Packaging
- 0.5MG
- Price
- $749
- Updated
- 2025/07/31
- Product number
- CS-0029213
- Product name
- Tertiapin-Q
- Purity
- 97.46%
- Packaging
- 5mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0029213
- Product name
- Tertiapin-Q
- Purity
- 97.46%
- Packaging
- 1mg
- Price
- $330
- Updated
- 2021/12/16
Tertiapin Q Chemical Properties,Usage,Production
Uses
Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1).
Biochem/physiol Actions
Blocks the GIRK1/4 and ROMK1 members of the inward-rectifier K+ channel family.
in vivo
Tertiapin-Q is a muscarinic acetylcholine receptor-operated K+ current (IK,Ach) blocker. After the cessation of rapid atrial pacing, the atrial effective refractory period (AERP) is unchanged during the experimental period in the rapid atrial pacing (RAP) rabbits (n=6). Bepridil (1 mg/kg, n=5 for each group), Amiodarone (10 mg/kg, n=5 for each group), Vernakalant (3 mg/kg, n=5 for each group), Ranolazine (10 mg/kg, n=6 for each group) or Tertiapin-Q (0.03 mg/kg, n=5 for each group) on the AERP in the control and RAP rabbits. Tertiapin-Q significantly prolongs the AERP at each pacing cycle length both in the control and RAP rabbits. The extents of prolonging effect of Tertiapin-Q on the AERP in the RAP rabbits are greater than those in the control animals[3].
storage
-20°C (desiccate)
References
[1] Picton LD, et al. Mechanisms underlying the endogenous dopaminergic inhibition of spinal locomotor circuit function in Xenopus tadpoles. Sci Rep. 2016 Oct 20;6:35749. DOI:10.1038/srep35749
[2] Günther T, et al. Research Resource: Real-Time Analysis of Somatostatin and Dopamine Receptor Signaling in Pituitary Cells Using a Fluorescence-Based Membrane Potential Assay. Mol Endocrinol. 2016 Apr;30(4):479-90. DOI:10.1210/me.2015-1241
[3] Chiba T, et al. Influences of rapid pacing-induced electrical remodeling on pharmacological manipulation of the atrial refractoriness in rabbits. J Pharmacol Sci. 2016 Mar;130(3):170-6. DOI:10.1016/j.jphs.2016.02.007
Tertiapin Q Preparation Products And Raw materials
Raw materials
Preparation Products
Tertiapin Q Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77