BAY-41-8543
- Product Name
- BAY-41-8543
- CAS No.
- 256498-66-5
- Chemical Name
- BAY-41-8543
- Synonyms
- BAY-41-8543;BAY-41-8543 Exclusive;BAY 41-8543 (BAY 418543);2-(1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl)-5-morpholinopyrimidine-4,6-diamine;2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine;2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine;4,6-Pyrimidinediamine, 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-;BAY 418543,vascular,systemic,antiplatelet,vasodilator,soluble,pulmonary,orally,nitric,beds,cardiovascular,BAY 41 8543,Guanylate Cyclase,Inhibitor,sGC,BAY 41-8543,oxide,inhibit
- CBNumber
- CB32590331
- Molecular Formula
- C21H21FN8O
- Formula Weight
- 420.44
- MOL File
- 256498-66-5.mol
BAY-41-8543 Property
- Boiling point:
- 599.7±50.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- solubility
- DMF: 3 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
- form
- A crystalline solid
- pka
- 5.18±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML2727
- Product name
- BAY 41-8543
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $101.65
- Updated
- 2025/07/31
- Product number
- SML2727
- Product name
- BAY 41-8543
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $433
- Updated
- 2025/07/31
- Product number
- 10011131
- Product name
- BAY 41-8543
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $35
- Updated
- 2024/03/01
- Product number
- 10011131
- Product name
- BAY 41-8543
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $114
- Updated
- 2024/03/01
- Product number
- 10011131
- Product name
- BAY 41-8543
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $210
- Updated
- 2024/03/01
BAY-41-8543 Chemical Properties,Usage,Production
Uses
BAY 41-8543, is a Guanylyl cyclase (sGC) stimulator, increasing the activity of recombinant sGC dose-dependently, from 0.1 nM to 100 μM, up to 92-fold. BAY 41-8543 reduces pulmonary vascular resistance and protects right ventricular (RV)function. It also inhibits collagen-induced platelet aggregation, and promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. It has also shown Antihypertensive activity.
Definition
ChEBI: BAY-41-8543 is a pyrazolopyridine.
in vivo
BAY 41-8543 (10-100 μg/kg; IV) produces small decreases in pulmonary arterial pressure, larger dose-dependent decreases in systemic arterial pressure, and increases in cardiac output[1].
BAY 41-8543 (0.003, 0.01, 0.03, 0.1, and 0.3?mg/kg; iv) produces a dose-dependent and long-lasting decrease in blood pressure in anaesthetized rats. The blood pressure lowering effect of BAY 41-8543 lasts longer than the observation period of 30?min. BAY 41-8543 (0.1, 0.3 and 1.0?mg?kg; oral) has maximal blood pressure lowering effects. The blood pressure lowering effects of the highest doses of BAY41-8543 lasts longer than the observation period of 120?min[2].
BAY 41-8543 (3?mg/kg; p.o.; twice daily; for 5 weeks) completely prevents the development of the increase in systolic blood pressure in 18-week-old renin transgenic rats (TGR(mRen2)27) on L-NAME treatment. BAY 41-8543 dramatically increases survival[2].
| Animal Model: | Adult male Sprague-Dawley rats weighing 325-450 g[1] |
| Dosage: | 10, 30, and 100 μg/kg |
| Administration: | IV |
| Result: | Produced small decreases in pulmonary arterial pressure, larger dose-dependent decreases in systemic arterial pressure, and increases in cardiac output. |
storage
Store at -20°C