1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride

1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride Property

storage temp. 

-20°C

solubility 

<46.55mg/ml in DMSO;insoluble in H2O

form 

solid

color 

White

Safety

Hazard Codes 

Xn,N

Risk Statements 

22-50

Safety Statements 

61

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride Chemical Properties,Usage,Production

Description

AMN082 is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7). It inhibits cAMP accumulation induced by forskolin in CHO cells expressing human mGluR7b (EC₅₀ = 64 nM). AMN082 (10 μM) is selective for mGluR7a and mGluR7b over mGluR1b, mGluR4, and mGluR8a with 140, 90, 15, 18, and 20% activation, respectively, as well as over mGluR2, mGluR3, mGluR5a, mGluR6, GluR3, and NMDA receptors containing NR1a, NR2A, or NR2B subunits. AMN082 also binds to the norepinephrine transporter (NET) and α₁-adrenergic receptor (α₁-AR). It increases the proliferation of neural progenitor cells (NPCs) and induces their differentiation into neurons when used at a concentration of 1 μM. AMN082 (2.5 mg/kg) inhibits apomorphine-induced circling in a rat model of Parkinson''s disease induced by 6-hydroxy dopamine (6-OHDA; ).

Uses

AMN082 dihydrochloride is a selective agonist at mGluR-7.

Definition

ChEBI: AMN082 dihydrochloride is a hydrochloride obtained by combining N,N'-bis(diphenylmethyl)ethane-1,2-diamine with two molar equivalent of hydrochloric acid. It has a role as a metabotropic glutamate receptor agonist, a geroprotector and a neuroprotective agent. It contains a N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+).

in vivo

treatment with amn082 was shown to penetrate into the brain and hence it modulated the level of stress hormones (acth and cortisol) in wild type animal. but these effects were not found in the mglur7 ko mouse [2].

storage

+4°C (desiccate)

References

[1]. pelkey ka, yuan x, lavezzari g, et al. mglur7 undergoes rapid internalization in response to activation by the allosteric agonist amn082. neuropharmacology, 2007, 52(1): 108-117.
[2]. gasparini f, spooren w. allosteric modulators for mglu receptors. current neuropharmacology, 2007, 5(3): 187-194.