L 656748
- Product Name
- L 656748
- CAS No.
- 121124-29-6
- Chemical Name
- L 656748
- Synonyms
- L 656748;EMaMectin B1a;Unii-IX4GP7848F;Emamectin B1a in Acetonitrile;Abamectin Impurity 17 Monomer;Avermectin impurity 17 monomer;Emamectin B1a 100 μg/ml in Acetonitrile;Avermectin A1a, 5-O-demethyl-4''-deoxy-4''-(methylamino)-, (4''R)-
- CBNumber
- CB32703722
- Molecular Formula
- C49H75NO13
- Formula Weight
- 886.12
- MOL File
- 121124-29-6.mol
L 656748 Property
- Boiling point:
- 935.0±65.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C, protect from light
- solubility
- DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
- form
- A solid
- pka
- 12.42±0.70(Predicted)
- Stability:
- Light Sensitive
N-Bromosuccinimide Price
- Product number
- 24060
- Product name
- Emamectin B1a
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $336
- Updated
- 2024/03/01
- Product number
- 24060
- Product name
- Emamectin B1a
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $1172
- Updated
- 2024/03/01
- Product number
- 448150
- Product name
- Emamectin B1a
- Packaging
- 1mg
- Price
- $779
- Updated
- 2021/12/16
- Product number
- E520505
- Product name
- EmamectinB1a
- Packaging
- 5mg
- Price
- $1000
- Updated
- 2021/12/16
L 656748 Chemical Properties,Usage,Production
Description
Emamectin B1a is a semisynthetic derivative of avermectin B1a . It binds to GABAA receptors (Ki = 17.6 nM in rat brain membranes), including those containing β1, β2, or β3 subunits (IC50s = 57, 210, and 49.8 nM for α1β1γ2, α1β2γ2, and α1β3γ2 subunits, respectively), and potentiates the GABA response. Emamectin B1a also binds to and inhibits glycine receptors (IC50 = 218 nM in rat spinal cord). Emamectin B1a induces mortality in 90% of S. exigua larvae in a diet incorporation assay at a dose of 1.067 ng/ml, which is approximately 1,500-fold more toxic than avermectin B1. It is effective against neonate S. eridania larvae in a foliage spray bioassay and when applied topically.
Uses
Emamectin B1a is a semi-synthetic 4”-epimethylamino analogue of avermectin B1a prepared by oxidation of the 4”-hydroxy moiety and reductive amination. The introduction of the methylamino group greatly enhances the insecticidal potency of the avermectin class. Emamectin B1a, as a benzoate salt, is the major component (>90%) of the commercial insecticide/acaricide, emamectin. Members of the avermectin/milbemycin class exert their insecticidal/anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells.
References
[1] H. MROZIK. Discovery of novel avermectins with unprecedented insecticidal activity[J]. Experientia. Supplementum, 1989, 42 1: 315-316. DOI: 10.1007/bf01951823
[2] G R DAWSON. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 295 3: 1051-1060.
L 656748 Preparation Products And Raw materials
Raw materials
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