ChemicalBook > CAS DataBase List > L 656748

L 656748

Product Name
L 656748
CAS No.
121124-29-6
Chemical Name
L 656748
Synonyms
L 656748;EMaMectin B1a;Unii-IX4GP7848F;Emamectin B1a in Acetonitrile;Abamectin Impurity 17 Monomer;Avermectin impurity 17 monomer;Emamectin B1a 100 μg/ml in Acetonitrile;Avermectin A1a, 5-O-demethyl-4''-deoxy-4''-(methylamino)-, (4''R)-
CBNumber
CB32703722
Molecular Formula
C49H75NO13
Formula Weight
886.12
MOL File
121124-29-6.mol
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L 656748 Property

Boiling point:
935.0±65.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C, protect from light
solubility 
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form 
A solid
pka
12.42±0.70(Predicted)
Stability:
Light Sensitive
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24060
Product name
Emamectin B1a
Purity
≥99%
Packaging
1mg
Price
$336
Updated
2024/03/01
Cayman Chemical
Product number
24060
Product name
Emamectin B1a
Purity
≥99%
Packaging
5mg
Price
$1172
Updated
2024/03/01
Usbiological
Product number
448150
Product name
Emamectin B1a
Packaging
1mg
Price
$779
Updated
2021/12/16
TRC
Product number
E520505
Product name
EmamectinB1a
Packaging
5mg
Price
$1000
Updated
2021/12/16
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L 656748 Chemical Properties,Usage,Production

Description

Emamectin B1a is a semisynthetic derivative of avermectin B1a . It binds to GABAA receptors (Ki = 17.6 nM in rat brain membranes), including those containing β1, β2, or β3 subunits (IC50s = 57, 210, and 49.8 nM for α1β1γ2, α1β2γ2, and α1β3γ2 subunits, respectively), and potentiates the GABA response. Emamectin B1a also binds to and inhibits glycine receptors (IC50 = 218 nM in rat spinal cord). Emamectin B1a induces mortality in 90% of S. exigua larvae in a diet incorporation assay at a dose of 1.067 ng/ml, which is approximately 1,500-fold more toxic than avermectin B1. It is effective against neonate S. eridania larvae in a foliage spray bioassay and when applied topically.

Uses

Emamectin B1a is a semi-synthetic 4”-epimethylamino analogue of avermectin B1a prepared by oxidation of the 4”-hydroxy moiety and reductive amination. The introduction of the methylamino group greatly enhances the insecticidal potency of the avermectin class. Emamectin B1a, as a benzoate salt, is the major component (>90%) of the commercial insecticide/acaricide, emamectin. Members of the avermectin/milbemycin class exert their insecticidal/anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells.

References

[1] H. MROZIK. Discovery of novel avermectins with unprecedented insecticidal activity[J]. Experientia. Supplementum, 1989, 42 1: 315-316. DOI: 10.1007/bf01951823
[2] G R DAWSON. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 295 3: 1051-1060.

L 656748 Preparation Products And Raw materials

Raw materials

Preparation Products

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L 656748 Suppliers

CHINA 30 India 1 United Kingdom 1 United States 4 Global 36
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19654
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
ShangHai Anpel Co, Ltd.
Tel
18501792038 18502138905
Email
shanpel@anpel.com.cn
Country
China
ProdList
9611
Advantage
58
Meng Cheng Technology (Shanghai) Co., LTD
Tel
400-820-6829
Email
sales@mitachieve.com
Country
China
ProdList
8860
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58

121124-29-6, L 656748Related Search:

EMaMectin B1b ABL PROTEIN TYROSINE KINASE

  • EMaMectin B1a
  • L 656748
  • Avermectin A1a, 5-O-demethyl-4''-deoxy-4''-(methylamino)-, (4''R)-
  • Unii-IX4GP7848F
  • Emamectin B1a 100 μg/ml in Acetonitrile
  • Emamectin B1a in Acetonitrile
  • Avermectin impurity 17 monomer
  • Abamectin Impurity 17 Monomer
  • 121124-29-6