ChemicalBook > CAS DataBase List > [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper

Product Name
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
CAS No.
68341-09-3
Chemical Name
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
Synonyms
CUAM;Cu-ASTM;Cu-ATSM;CuII(atsm);Cu-ASTM >=98% (HPLC);Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II);[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
CBNumber
CB32750504
Molecular Formula
C8H14CuN6S2
Formula Weight
321.91296
MOL File
68341-09-3.mol
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[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Property

storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
color 
brown to dark red-brown
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0769
Product name
Cu-ASTM
Purity
≥98% (HPLC)
Packaging
5mg
Price
$126
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0769
Product name
Cu-ASTM
Purity
≥98% (HPLC)
Packaging
25mg
Price
$471.2
Updated
2025/07/31
Cayman Chemical
Product number
17122
Product name
Cu-ATSM
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17122
Product name
Cu-ATSM
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
17122
Product name
Cu-ATSM
Purity
≥95%
Packaging
10mg
Price
$169
Updated
2024/03/01
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[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Chemical Properties,Usage,Production

Uses

Cu-ATSM is preclinically used as a potential therapy for ALS (amyotrophic lateral sclerosis). A potential anti-Alzheimer''s agent.

Biochem/physiol Actions

Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that specifically inhibits the action of peroxynitrite on Cu,Zn superoxide dismutase (SOD1) and subsequent nitration of cellular proteins. CuII(ATSM) significantly delayed onset of disease (paralysis and prolonged lifespan) in amyotrophic lateral sclerosis (ALS) mice model. Also, Cu-ATSM was reported to lower lipid peroxidation in a model of ischemicreperfusion injury. Cu-ATSM subsequently was shown to inhibit ferroptosis with a potency similar to Liproxstatin-1.

in vivo

CuATSM (1.5 mg/kg, iv, single dose) reduces cerebral infarct volume and oxidative stress, exhibits neuroprotective effect against ischemic stroke in mouse model[2].

Animal Model:Mouse transient middle cerebral artery occlusion (tMCAO) model[2]
Dosage:1.5 mg/kg
Administration:iv, single dose
Result:Reduced the expression of oxidative stress markers such as 4-HNE, 8-OHdG, and nitrotyrosine.

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Preparation Products And Raw materials

Raw materials

Preparation Products

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[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Suppliers

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68341-09-3, [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copperRelated Search:


  • [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
  • Cu-ASTM
  • CuII(atsm)
  • Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II)
  • CUAM
  • Cu-ATSM
  • Cu-ASTM >=98% (HPLC)
  • 68341-09-3