ChemicalBook > CAS DataBase List > [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper

Product Name
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
CAS No.
68341-09-3
Chemical Name
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
Synonyms
CUAM;Cu-ASTM;Cu-ATSM;CuII(atsm);Cu-ASTM >=98% (HPLC);Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II);[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
CBNumber
CB32750504
Molecular Formula
C8H14CuN6S2
Formula Weight
321.91296
MOL File
68341-09-3.mol
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[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Property

storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
color 
brown to dark red-brown
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0769
Product name
Cu-ASTM
Purity
≥98% (HPLC)
Packaging
5mg
Price
$126
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0769
Product name
Cu-ASTM
Purity
≥98% (HPLC)
Packaging
25mg
Price
$471.2
Updated
2025/07/31
Cayman Chemical
Product number
17122
Product name
Cu-ATSM
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17122
Product name
Cu-ATSM
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
17122
Product name
Cu-ATSM
Purity
≥95%
Packaging
10mg
Price
$169
Updated
2024/03/01
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[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Chemical Properties,Usage,Production

Uses

Cu-ATSM is preclinically used as a potential therapy for ALS (amyotrophic lateral sclerosis). A potential anti-Alzheimer''s agent.

Biochem/physiol Actions

Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that specifically inhibits the action of peroxynitrite on Cu,Zn superoxide dismutase (SOD1) and subsequent nitration of cellular proteins. CuII(ATSM) significantly delayed onset of disease (paralysis and prolonged lifespan) in amyotrophic lateral sclerosis (ALS) mice model. Also, Cu-ATSM was reported to lower lipid peroxidation in a model of ischemicreperfusion injury. Cu-ATSM subsequently was shown to inhibit ferroptosis with a potency similar to Liproxstatin-1.

in vivo

CuATSM (1.5 mg/kg, iv, single dose) reduces cerebral infarct volume and oxidative stress, exhibits neuroprotective effect against ischemic stroke in mouse model[2].

Animal Model:Mouse transient middle cerebral artery occlusion (tMCAO) model[2]
Dosage:1.5 mg/kg
Administration:iv, single dose
Result:Reduced the expression of oxidative stress markers such as 4-HNE, 8-OHdG, and nitrotyrosine.

[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Preparation Products And Raw materials

Raw materials

Preparation Products

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[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Suppliers

China 30 United States 4 Global 34
YangZhou Ruihong Biotech Co., Ltd.
Tel
0514-015380367604 15380367604
Fax
0514-83828236
Email
sales@ruibobiotech.com
Country
China
ProdList
511
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55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9273
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shanghai Taopu Industrial Co., LTD
Tel
159-00573766 18018507602
Email
394643792@qq.com
Country
China
ProdList
4328
Advantage
58

68341-09-3, [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copperRelated Search:


  • [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
  • Cu-ASTM
  • CuII(atsm)
  • Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II)
  • CUAM
  • Cu-ATSM
  • Cu-ASTM >=98% (HPLC)
  • 68341-09-3