[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
- Product Name
- [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
- CAS No.
- 68341-09-3
- Chemical Name
- [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
- Synonyms
- CUAM;Cu-ASTM;Cu-ATSM;CuII(atsm);Cu-ASTM >=98% (HPLC);Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II);[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
- CBNumber
- CB32750504
- Molecular Formula
- C8H14CuN6S2
- Formula Weight
- 321.91296
- MOL File
- 68341-09-3.mol
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Property
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- color
- brown to dark red-brown
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0769
- Product name
- Cu-ASTM
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $126
- Updated
- 2025/07/31
- Product number
- SML0769
- Product name
- Cu-ASTM
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $471.2
- Updated
- 2025/07/31
- Product number
- 17122
- Product name
- Cu-ATSM
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17122
- Product name
- Cu-ATSM
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 17122
- Product name
- Cu-ATSM
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $169
- Updated
- 2024/03/01
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Chemical Properties,Usage,Production
Uses
Cu-ATSM is preclinically used as a potential therapy for ALS (amyotrophic lateral sclerosis). A potential anti-Alzheimer''s agent.
Biochem/physiol Actions
Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that specifically inhibits the action of peroxynitrite on Cu,Zn superoxide dismutase (SOD1) and subsequent nitration of cellular proteins. CuII(ATSM) significantly delayed onset of disease (paralysis and prolonged lifespan) in amyotrophic lateral sclerosis (ALS) mice model. Also, Cu-ATSM was reported to lower lipid peroxidation in a model of ischemicreperfusion injury. Cu-ATSM subsequently was shown to inhibit ferroptosis with a potency similar to Liproxstatin-1.
in vivo
CuATSM (1.5 mg/kg, iv, single dose) reduces cerebral infarct volume and oxidative stress, exhibits neuroprotective effect against ischemic stroke in mouse model[2].
| Animal Model: | Mouse transient middle cerebral artery occlusion (tMCAO) model[2] |
| Dosage: | 1.5 mg/kg |
| Administration: | iv, single dose |
| Result: | Reduced the expression of oxidative stress markers such as 4-HNE, 8-OHdG, and nitrotyrosine. |
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Preparation Products And Raw materials
Raw materials
Preparation Products
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Suppliers
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