MG-132

ChemicalBook > CAS DataBase List > MG-132

Product Name: MG-132
CAS No.: 133407-82-6
Chemical Name: MG-132
Synonyms: MG-132;CS-216;Z-LL-CHO;Z-LLL-al;Z-LLL-CHO;(S)-MG132;MG-132(SSS);MG132/MG-132;MG-132, >=98%;Z-LEU-LEU-LEU-H
CBNumber: CB3298042
Molecular Formula: C26H41N3O5
Formula Weight: 475.62
MOL File: 133407-82-6.mol

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MG-132 Property

Melting point:: 80-84℃ (DEC.)
alpha: -61～-67°
Boiling point:: 682.0±55.0 °C(Predicted)
Density: 1.073
Flash point:: 366℃
storage temp.: -20°C
solubility: methanol: 1 mg/mL
form: solid film
pka: 11.14±0.46(Predicted)
color: White
Water Solubility: Soluble in ethanol, chloroform, methanol, water.
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.
InChIKey: TZYWCYJVHRLUCT-VABKMULXSA-N

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Safety

Risk Statements: 36/37/38
Safety Statements: 24/25
WGK Germany: 3
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 474790
Product name: MG-132
Purity: A cell-permeable, potent, reversible proteasome inhibitor (K
Packaging: 1mg
Price: $56.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 474787
Product name: MG-132, ≥95% by HPLC
Packaging: 10mg
Price: $85.2
Updated: 2024/03/01

Alfa Aesar

Product number: J63250
Product name: MG 132
Packaging: 1mg
Price: $35.4
Updated: 2023/06/20

Alfa Aesar

Product number: J63250
Product name: MG 132
Packaging: 5mg
Price: $134
Updated: 2023/06/20

Cayman Chemical

Product number: 10012628
Product name: (S)-MG132
Purity: ≥98%
Packaging: 1mg
Price: $20
Updated: 2024/03/01

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MG-132 Chemical Properties,Usage,Production

Description

MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM).1 Suppresses gastric cancer cell proliferation and induces macro-autophagy.2 Activates stress kinases and induces Hsp72.3 Induces neurite outgrowth.1 MG-132 blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM).4 Cell permeable.

Uses

A proteasome and NF-κB inhibitor.

Uses

MG 132 is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells. Neuroprotective product.

Definition

ChEBI: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.

General Description

Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) and inhibits NF-κB activation (IC₅₀ = 3 μM).

Biological Activity

Potent cell-permeable inhibitor of proteasome (IC 50 = 100 nM) and calpain (IC 50 = 1.2 μ M). Inhibits TNF- α -induced NF- κ B activation and I κ B α degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro .

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C (desiccate)

References

1) Tsubuki et al. (1996), Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine; J. Biochem.,? 119 572 2) Wu? et al. (2010), Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells; Autophagy, 6 228 3) Meriin? et al. (1998), Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis; J. Biol. Chem., 273 6373 4) Fiedler et al. (1998), Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132; Am. J. Respir. Cell Mol. Biol., 19 259

MG-132 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MG-132 manufacturers

Career Henan Chemical Co

Product: MG-132 133407-82-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 2tons
Release date: 2019-12-19

133407-82-6, MG-132Related Search:

MG-115 Z-Leu-Leu-Beta-Hotyr-al ACHROMOPEPTIDASE Trypsin trysin-chymotrypsin Basic protease CALPAIN INHIBITOR I MG-132 Calpain Inhibitor I LACTACYSTIN L-Leu-Leu-Leu Z-LLL-AMC Z-LEU-LEU-LEU-FMK MG-262 CALPAIN INHIBITOR IV MG-132 in Solution 1 MG PROTEASOME INHIBITOR MG-132Z-LEU-LEU-LEU-H (ALDEHYDE) 5 MG PROTEASOME INHIBITOR MG-132Z-LEU-LEU-LEU-H (ALDEHYDE)

PROTEASOME INHIBITOR MG-132

N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-N-[(1S)-1-FORMYL-3-METHYLBUTYL]-L-LEUCINAMIDE

N-CBZ-LEU-LEU-LEUCINAL

MG-132

Z-LLL-CHO

Z-LL-CHO

Z-LEU-LEU-LEU-CHO

Z-LEU-LEU-LEU-H

Z-LEU-LEU-LEU-H (ALDEHYDE)

Z-LEU-LEU-LEU-ALDEHYDE

Z-LEU-LEU-ALDEHYDE

N-cbz-leu-leu-leu-al

z-leu-leu-leu-al

CALPAIN INHIBITOR IV

CARBOBENZOXY-L-LEUCYL-L-LEUCYL-LEUCINAL

CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL

BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-LEUCINAL

benzyloxycarbonylleucyl-leucyl-leucinealdehyde

(S)-MG132

N-carbobenzyloxy-Leu-Leu-Leu-al

MG-132;Z-LEU-LEU-LEU-AL

Z-Leu-Leu-Leu-al,MG132

Calpain inhibitor IV-2

MG 132;MG132;Z-LEU-LEU-LEU-CHO;CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL

L-LeucinaMide, N-[(phenylMethoxy)carbonyl]-L-leucyl-N-[(1S)-1-forMyl-3-Methylbutyl]-

MG132/MG-132

MG-132 [Z-Leu-Leu-Leu-CHO]

Z-LEU-LEU-LEU-AL, >=90% (HPLC)

Benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylami

InSolution? MG-132

MG-132, ≥95% by HPLC

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal

MG132, 98%, proteasome inhibitor

benzyl ((S)-4-Methyl-1-(((S)-4-Methyl-1-(((S)-4-Methyl-1-oxopentan-2-yl)aMino)-1-oxopentan-2-yl)aMino)-1-oxopentan-2-yl)carbaMate

MG 132 Calpain inhibitor IV-2

N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide Calpain inhibitor IV-2 MG 132

MG-132, >=98%

CS-216

MG-132 - CAS 133407-82-6 - Calbiochem

MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem

InSolution MG-132 - CAS 133407-82-6 - Calbiochem

benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

Z-LLL-al

133407-82-6 MG-132 C26H41N3O5

MG-132,Inhibitor,MG132,MG 132,complex,peptide,calpain,Autophagy,proteolytic,Proteasome,aldehyde,inhibit,Apoptosis,26S

MG-132 solution (10mM/L)

MG-132(SSS)

MG-132 (Ethanol Solution)

(S)-2-(Cbz-amino)-4-methyl-N-[(S)-4-methyl-1-[[(S)-4-methyl-1-oxo-2-pentyl]amino]-1-oxo-2-pentyl]pentanamide

MG-132 (Ethanol Solution), proteasome inhibitor

MG-132, proteasome inhibitor

133407-82-6

C26H41N3O5

Cell Signaling Enzymes

BioChemical

Biochemicals and Reagents

Application Index

Enzymes, Inhibitors, and Substrates