Verosudil

Product Name: Verosudil
CAS No.: 1414854-42-4
Chemical Name: Verosudil
Synonyms: Verosudil;Verosudil(AR-12286);Verosudil, 10 mM in DMSO;3-Thiopheneacetamide, N-(1,2-dihydro-1-oxo-6-isoquinolinyl)-α-(dimethylamino)-;N-(1,2-Dihydro-1-oxo-6-isoquinolinyl)-alpha-(dimethylamino)-3-thiopheneacetamide;2-(Dimethylamino)-N-(1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide
CBNumber: CB33038526
Molecular Formula: C17H17N3O2S
Formula Weight: 327.4
MOL File: 1414854-42-4.mol

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Verosudil Property

Boiling point:: 625.5±55.0 °C(Predicted)
Density: 1.328±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
pka: 13.70±0.20(Predicted)
form: Solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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Verosudil Chemical Properties,Usage,Production

Uses

Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2].

IC 50

ROCK1: 2 nM (Ki); ROCK2: 2 nM (Ki); PKA: 69 nM (Ki); MRCKA: 28 nM (Ki); CAM2A: 5855 nM (Ki); PKC theta: 9322 nM (Ki)

References

[1] Lin CW, Sherman B, Moore LA, et al. Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. J Ocul Pharmacol Ther. 2018;34(1-2):40‐51. DOI:10.1089/jop.2017.0023
[2] Kopczynski C, Novack GD, Swearingen D, van Haarlem T. Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers. Br J Ophthalmol. 2013;97(5):567‐572. DOI:10.1136/bjophthalmol-2012-302466

Verosudil Preparation Products And Raw materials

Raw materials

Preparation Products

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Verosudil Suppliers

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1414854-42-4, VerosudilRelated Search:

Verosudil

N-(1,2-Dihydro-1-oxo-6-isoquinolinyl)-alpha-(dimethylamino)-3-thiopheneacetamide

Verosudil(AR-12286)

3-Thiopheneacetamide, N-(1,2-dihydro-1-oxo-6-isoquinolinyl)-α-(dimethylamino)-

Verosudil, 10 mM in DMSO

2-(Dimethylamino)-N-(1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide

1414854-42-4