Verosudil

Verosudil Property

Boiling point:

625.5±55.0 °C(Predicted)

Density 

1.328±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)

pka

13.70±0.20(Predicted)

form 

Solid

color 

White to light yellow

Hazard and Precautionary Statements (GHS)

Verosudil Chemical Properties,Usage,Production

Uses

Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2].

IC 50

ROCK1: 2 nM (Ki); ROCK2: 2 nM (Ki); PKA: 69 nM (Ki); MRCKA: 28 nM (Ki); CAM2A: 5855 nM (Ki); PKC theta: 9322 nM (Ki)

References

[1] Lin CW, Sherman B, Moore LA, et al. Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. J Ocul Pharmacol Ther. 2018;34(1-2):40‐51. DOI:10.1089/jop.2017.0023
[2] Kopczynski C, Novack GD, Swearingen D, van Haarlem T. Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers. Br J Ophthalmol. 2013;97(5):567‐572. DOI:10.1136/bjophthalmol-2012-302466