MI-192

Product Name: MI-192
CAS No.: 1415340-63-4
Chemical Name: MI-192
Synonyms: MI-192;MI-192 hydrochloride;MI-192 hydrochloride, HDAC2/3 inhibitor;N-(2-Aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]benzamide;Benzamide, N-(2-aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]-
CBNumber: CB33039886
Molecular Formula: C24H21N3O2
Formula Weight: 383.44
MOL File: 1415340-63-4.mol

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MI-192 Property

Boiling point:: 565.0±50.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: ≤5mg/ml in DMSO;1mg/ml in dimethyl formamide
pka: 13.08±0.70(Predicted)
form: powder
color: white to light brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1451
Product name: MI192 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $96.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1451
Product name: MI192 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $564
Updated: 2023/01/07

Cayman Chemical

Product number: 18288
Product name: MI-192
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18288
Product name: MI-192
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18288
Product name: MI-192
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

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MI-192 Chemical Properties,Usage,Production

Uses

MI-192 is a histone deacetylase (HDAC) 2 and 3 inhibitor. It also showed cytotoxic effect by inducing differentiation and apoptosis in acute myeloid leukemia cells in human.

Biological Activity

mi-192 is a histone deacetylases (hdacs) inhibitor that preferentially inhibits hdac2 and hdac3 with ic50 values of 30 nm and 16 nm, respectively [1].histone acetylation is the most commonly employed mechanism utilized by transcription factors to activate gene expression. conversely, histone deacetylation is the most common mechanism used to inactivate genes. histone deacetylase inhibitors (hdacis) are in advanced clinical development as cancer therapeutic agents [1].mi-192 is a novel benzamide-based compound that had marked selectivity for the class i enzymes, hdac2 and hdac3. in hela cell extracts, mi-192 inhibited hdac activity with ic50 value of 1.5 μm. mi-192 selectively inhibited recombinant hdac2 and hdac3 with ic50 values of 30 nm and 16 nm, respectively over hdac1, 4, 6, 7, and 8 (ic50s = 4.8, 5, >10, 4.1, and >10 μm, respectively). mi-192 showed the greatest growth inhibitory effect against the leukemic cell lines with an effective dose of 0.1-0.4 μm. mi-192 was cytotoxic and promoted apoptosis and differentiation in leukaemic cell lines [1]. in the human prostate cancer cell line pc3, mi-192 significantly increased tubulin acetylation and ablated the dynamic behaviour of microtubules in live cells [2].

Biochem/physiol Actions

MI192 is a potent and selective histone deacetylase 3 (HDAc 3) inhibitor that inhibits IL-6 production in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) but not healthy PBMCs.

References

[1]. boissinot, m.,inman, m.,hempshall, a., et al. induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor mi-192. leukemia research 36, 1304-1310 (2012).
[2]. bacon t, seiler c, wolny m, et al. histone deacetylase 3 indirectly modulates tubulin acetylation. biochem j. 2015 dec 15;472(3):367-77.

MI-192 Preparation Products And Raw materials

Raw materials

Preparation Products

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MI-192 Suppliers

China 29 United Kingdom 1 United States 7 Global 37

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1415340-63-4, MI-192Related Search:

MI-192

MI-192 hydrochloride

N-(2-Aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]benzamide

Benzamide, N-(2-aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]-

MI-192 hydrochloride, HDAC2/3 inhibitor

1415340-63-4