Urodilatin (human)

Product Name: Urodilatin (human)
CAS No.: 118812-69-4
Chemical Name: Urodilatin (human)
Synonyms: L-Tyrosine, L-threonyl-L-alanyl-L-prolyl-L-arginyl-L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenyla...
CBNumber: CB33051053
Molecular Formula: C145H234N52O44S3
Formula Weight: 3505.97
MOL File: 118812-69-4.mol

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Urodilatin (human) Property

Density: 1.56±0.1 g/cm3(Predicted)
Sequence: H-Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH ?(Disulfide bridge Cys11-Cys27)
InChIKey: IUCCYQIEZNQWRS-JVMWJOHJNA-N

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Hazard and Precautionary Statements (GHS)

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Urodilatin (human) Chemical Properties,Usage,Production

Uses

Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure[1][2][4][5].

in vivo

Ularitide (10?nmol/kg, s.c., once) increases in urine volume and sodium excretion in arteriovenous (AV) fistula dogs^[1].

Animal Model:	Female dogs with or without surgically induced chronic aortocaval fistula^[1]
Dosage:	5 and 10 pmol/kg/min
Administration:	i.v. infusions for for 75 min, and thereafter at 10 pmol/kg/min for another 75 min.
Result:	Increased in urine volume and sodium excretion with high-output CHF.

References

[1] Anker SD, et al. Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies. Eur Heart J. 2015 Mar 21;36(12):715-23.
[2] Korn C, et al. Comparison of the effects of ularitide acetate and other bronchorelaxing substances on the thrombin-induced permeability raise of human endothelial cell monolayers. Arzneimittelforschung. 1998 Mar;48(3):251-8. PMID:9553682
[3] Nally JE, et al. Bronchodilator and pre-protective effects of urodilatin in bovine bronchi in vitro: comparison with atrial natriuretic peptide. Br J Pharmacol. 1995 Apr;114(7):1391-6. DOI:10.1111/j.1476-5381.1995.tb13360.x
[4] Valentin JP, et al. Urodilatin binds to and activates renal receptors for atrial natriuretic peptide. Hypertension. 1993 Apr;21(4):432-8. DOI:10.1161/01.hyp.21.4.432
[5] Choi MR, et al. Urodilatin regulates renal dopamine metabolism. J Nephrol. 2013 Nov-Dec;26(6):1042-8. DOI:10.5301/jn.5000279

Urodilatin (human) Preparation Products And Raw materials

Raw materials

Preparation Products

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Urodilatin (human) Suppliers

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View Lastest Price from Urodilatin (human) manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: Urodilatin (human) 118812-69-4
Price: US $20.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-20

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Urodilatin (human) 118812-69-4
Price: US $65.00-650.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-28

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L-Tyrosine, L-threonyl-L-alanyl-L-prolyl-L-arginyl-L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenyla...

118812-69-4