CCT251545

ChemicalBook > CAS DataBase List > CCT251545

Product Name: CCT251545
CAS No.: 1661839-45-7
Chemical Name: CCT251545
Synonyms: CS-2537;CCT251545;LM-3773,CCT251545;CCT-251545;CCT 251545;inhibit,Wnt,CCT251545,Inhibitor,CCT-251545,CCT 251545;8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one;8-[3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one;2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-
CBNumber: CB33067003
Molecular Formula: C23H24ClN5O
Formula Weight: 421.92
MOL File: 1661839-45-7.mol

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CCT251545 Property

Boiling point:: 709.7±60.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: ≥42.2 mg/mL in DMSO; insoluble in H2O; ≥2.33 mg/mL in EtOH with ultrasonic
form: solid
pka: 15.81±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18761
Product name: CCT251545
Purity: ≥95%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 18761
Product name: CCT251545
Purity: ≥95%
Packaging: 5mg
Price: $190
Updated: 2024/03/01

Cayman Chemical

Product number: 18761
Product name: CCT251545
Purity: ≥95%
Packaging: 10mg
Price: $333
Updated: 2024/03/01

TRC

Product number: C227973
Product name: CCT251545
Packaging: 1mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-5359
Product name: CCT251545
Purity: 99.27%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

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CCT251545 Chemical Properties,Usage,Production

Description

CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC₅₀ = 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19. Through its effects on Cdk8 and Cdk19, CCT251545 alters Wnt pathway-regulated gene expression. It reduces tumor growth in COLO 205 human colon cancer xenografts after oral dosing (70 mg/kg bid) and in Wnt-dependent tumors.

Uses

CCT251545 is a potent inhibitor of WNT signaling with good oral pharmacokinetics.

Definition

ChEBI: CCT251545 is a chloropyridine that is 3-chloropyridine substituted by a 1-oxo-2,8-diazaspiro[4.5]decan-8-yl group and a 4-(1-methyl-1H-pyrazol-4-yl)phenyl group at positions 4 and 5, respectively. It is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM) and a potent and selective chemical probe for cyclin-dependent kinases CDK8 and CDK19. It has a role as a Wnt signalling inhibitor, an antineoplastic agent and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a chloropyridine, a member of pyrazoles and an azaspiro compound.

References

[1]. mallinger a, crumpler s, pichowicz m, et al. discovery of potent, orally bioavailable, small-molecule inhibitors of wnt signaling from a cell-based pathway screen. j med chem, 2015, 58(4): 1717-1735.
[2]. dale t, clarke pa, esdar c, et al. a selective chemical probe for exploring the role of cdk8 and cdk19 in human disease. nat chem biol, 2015, 11(12): 973-980.

CCT251545 Preparation Products And Raw materials

Raw materials

Preparation Products

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1661839-45-7, CCT251545Related Search:

1-tert-butyl 4-methyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate 3-BroMo-4,5-dichloropyridine 8-(3-bromo-5-chloropyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one 1-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrazole 4-(4-CHLOROPHENYL)-1-METHYL-1H-PYRAZOLE

CCT251545

8-[3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one

LM-3773,CCT251545

8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

CS-2537

CCT-251545;CCT 251545

2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-

inhibit,Wnt,CCT251545,Inhibitor,CCT-251545,CCT 251545

1661839-45-7

1661839-45-1

C23H24ClN5O