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CAY10640

Product Name
CAY10640
CAS No.
1208549-68-1
Chemical Name
CAY10640
Synonyms
CAY10640;1-[1-(cyclopropanecarbonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea;Urea, N-[1-(cyclopropylcarbonyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-
CBNumber
CB33152574
Molecular Formula
C17H20F3N3O3
Formula Weight
371.35
MOL File
1208549-68-1.mol
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CAY10640 Property

Melting point:
195-196 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling point:
470.8±45.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): Isoluble
form 
A crystalline solid
pka
13.11±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10642
Product name
CAY10640
Purity
≥98%
Packaging
1mg
Price
$54
Updated
2024/03/01
Cayman Chemical
Product number
10642
Product name
CAY10640
Purity
≥98%
Packaging
5mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
10642
Product name
CAY10640
Purity
≥98%
Packaging
10mg
Price
$328
Updated
2024/03/01
AK Scientific
Product number
2947DG
Product name
1-(1-Cyclopropanecarbonylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
Packaging
1mg
Price
$156
Updated
2021/12/16
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CAY10640 Chemical Properties,Usage,Production

Description

Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM.1 CAY10640 demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model.1

Uses

sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively[1].

in vivo

Pharmacokinetic parameters of sEH inhibitor-1 (TCPU) after oral gavage with a non-compartmental analysis[1].

Doses (mg/kg)Cmaxa (nmol/L)Tmax (h)aAUCt (uM h)aMRT (h)a
0.1 (0.27d)270±1205.3±1.22.2±1.118.9±6.6
0.3 (0.81d)1680±11704.7±1.216.6±8.816.9±5.4
1.0 (2.69d)2560±953.2±2.243.8±5.124.0±1.8
3.0 (8.08d)5160±2653.9±2.594.3±8.032.1±5.6
a: Tmax, the time of maximum concentration; Cmax, the maximum blood concentration; MRT, the mean residence time; and AUCt, area under the concentration-time curve to terminal time. Additional PK parameters with non-compartmental model are presented in Table S3.
d: The dose with the unit of μmol/kg.

References

1. Rose, T.E., Morisseau, C., Liu, J.Y., et al. 1-aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: Structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain J. Med. Chem. 53(19),7067-7075(2010).

CAY10640 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10640 Suppliers

China 30 United States 3 Global 33
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1208549-68-1, CAY10640Related Search:


  • CAY10640
  • 1-[1-(cyclopropanecarbonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
  • Urea, N-[1-(cyclopropylcarbonyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-
  • 1208549-68-1