Omadacycline (hydrochloride)

Product Name: Omadacycline (hydrochloride)
CAS No.: 1196800-39-1
Chemical Name: Omadacycline (hydrochloride)
Synonyms: omadacycline HCl;PTK0796 hydrochloride;PTK-0796 hydrochloride;PTK 0796 hydrochloride;Amadacycline hydrochloride;Omadacycline (hydrochloride);Omadacycline hydrochloride (PTK0796 hydrochloride);PTK 0796 HYDROCHLORIDE; PTK-0796 HYDROCHLORIDE; PTK0796 HYDROCHLORIDE; AMADACYCLINE HYDROCHLORIDE;(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-9-[(2,2-dimethylpropylamino)methyl]-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-((neopentylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
CBNumber: CB33167628
Molecular Formula: C29H41ClN4O7
Formula Weight: 593.12
MOL File: 1196800-39-1.mol

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Omadacycline (hydrochloride) Property

storage temp.: Store at -20°C
form: Solid
color: Brown to black
Water Solubility: Water : ≥ 50 mg/mL (84.30 mM)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6352
Product name: Omadacycline(hydrochloride)
Purity: 99.87%
Packaging: 5mg
Price: $312
Updated: 2021/12/16

ChemScene

Product number: CS-6352
Product name: Omadacycline(hydrochloride)
Purity: 99.87%
Packaging: 10mg
Price: $540
Updated: 2021/12/16

ChemScene

Product number: CS-6352
Product name: Omadacycline(hydrochloride)
Purity: 99.87%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

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Omadacycline (hydrochloride) Chemical Properties,Usage,Production

Description

Omadacycline, also known as PTK 0796 and Amadacyclin, is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired methicillin-resistant Staphylococcus aureus (MRSA), β-hemolytic streptococci, penicillin-resistant Streptococcus pneumoniae, Haemophilus influenzae, and Legionella. Omadacycline is active against strains expressing the two main forms of tetracycline resistance (efflux and ribosomal protection). The primary effect of omadacycline is on bacterial protein synthesis, inhibiting protein synthesis with a potency greater than that of tetracycline. The binding site for omadacycline is similar to that for tetracycline.

Uses

Omadacycline (PTK 0796) hydrochloride, a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections[1][2][3][4].

in vivo

Omadacycline (0.11-18 mg/kg; a single i.v.) exhibits efficacy against Streptococcus pneumonia, Escherichia coli, and Staphylococcus aureus in mice systemic infection model, with ED₅₀s ranging from 0.30 mg/kg to 3.39 mg/kg^[2].

IC 50

Tetracycline

References

[1] Dur?es F, et, al. Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines. Pharmaceuticals (Basel). 2019 Apr 21;12(2):63. DOI:10.3390/ph12020063
[2] Macone AB, et, al. In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline. Antimicrob Agents Chemother. 2014;58(2):1127-35. DOI:10.1128/AAC.01242-13
[3] Zhanel GG, et, al. Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent. Drugs. 2020 Feb;80(3):285-313. DOI:10.1007/s40265-020-01257-4
[4] Markham A, et, al. Omadacycline: First Global Approval. Drugs. 2018 Dec;78(18):1931-1937. DOI:10.1007/s40265-018-1015-2

Omadacycline (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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Omadacycline (hydrochloride) Suppliers

China 25 United States 5 Global 30

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1196800-39-1, Omadacycline (hydrochloride)Related Search:

Omadacycline (hydrochloride)

(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-9-[(2,2-dimethylpropylamino)methyl]-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

Amadacycline hydrochloride

PTK 0796 hydrochloride

PTK 0796 HYDROCHLORIDE; PTK-0796 HYDROCHLORIDE; PTK0796 HYDROCHLORIDE; AMADACYCLINE HYDROCHLORIDE

PTK0796 hydrochloride

PTK-0796 hydrochloride

omadacycline HCl

(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-((neopentylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride

Omadacycline hydrochloride (PTK0796 hydrochloride)

1196800-39-1

C29H41ClN4O7