ChemicalBook > CAS DataBase List > 2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol

2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol

Product Name
2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol
CAS No.
1436383-95-7
Chemical Name
2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol
Synonyms
BF738735;BF738735 (BF 738735;BF738735, 10 mM in DMSO;PI4KIIIβ Inhibitor, BF738735;2-Fluoro-4-[2-methyl-8-[[3-(methylsulfonyl)benzyl]amino]-3-imidazo[1,2-a]pyrazinyl]phenol;2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol;Phenol, 2-fluoro-4-[2-methyl-8-[[[3-(methylsulfonyl)phenyl]methyl]amino]imidazo[1,2-a]pyrazin-3-yl]-;BF738735,Phosphatidylinositol 4 kinases,Inhibitor,BF 738735,PI4 kinases,inhibit,BF-738735,Reverse Transcriptase,PI4K
CBNumber
CB33303776
Molecular Formula
C21H19FN4O3S
Formula Weight
426.46
MOL File
1436383-95-7.mol
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2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol Property

Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 125 mg/mL (293.11 mM)
pka
8.08±0.20(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.33657
Product name
PI4KIIIβ Inhibitor, BF738735
Packaging
10 mg
Price
$203
Updated
2025/07/31
Tocris
Product number
6246
Product name
BF738735
Purity
≥98%(HPLC)
Packaging
10
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0035356
Product name
BF738735
Purity
99.10%
Packaging
10mg
Price
$190
Updated
2021/12/16
ChemScene
Product number
CS-0035356
Product name
BF738735
Purity
99.10%
Packaging
25mg
Price
$410
Updated
2021/12/16
ChemScene
Product number
CS-0035356
Product name
BF738735
Purity
99.10%
Packaging
5mg
Price
$110
Updated
2021/12/16
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2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol Chemical Properties,Usage,Production

Uses

BF738735 is a phosphatidylinositol 4-kinase III beta (PI4KIIIβ) inhibitor with an IC50 of 5.7 nM.

Biological Activity

Cell permeable: yes', 'Primary Target
PI4KIII&beta', 'Reversible: yes

in vivo

BF738735 is well tolerated by specimens with good plasma levels of the antiviral in circulation and a complete inhibition with 25 mg/kg and some inhibition with 5 mg/kg dose is observed[2].

IC 50

PI4KIIIβ: 5.7 nM (IC50); PI4KIIIα: 1.7 μM (IC50)

storage

Store at -20°C

References

[1] van der Schaar HM, et al. A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ. Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81. DOI:10.1128/AAC.01175-13
[2] V Saarnio. Antiviral Molecules of Enteroviruses. 13.1.2017.

2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol Suppliers

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1436383-95-7, 2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenolRelated Search:


  • 2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol
  • BF738735
  • BF738735 (BF 738735
  • Phenol, 2-fluoro-4-[2-methyl-8-[[[3-(methylsulfonyl)phenyl]methyl]amino]imidazo[1,2-a]pyrazin-3-yl]-
  • BF738735,Phosphatidylinositol 4 kinases,Inhibitor,BF 738735,PI4 kinases,inhibit,BF-738735,Reverse Transcriptase,PI4K
  • 2-Fluoro-4-[2-methyl-8-[[3-(methylsulfonyl)benzyl]amino]-3-imidazo[1,2-a]pyrazinyl]phenol
  • BF738735, 10 mM in DMSO
  • PI4KIIIβ Inhibitor, BF738735
  • 1436383-95-7