ChemicalBook > CAS DataBase List > VU 0409551

VU 0409551

Product Name
VU 0409551
CAS No.
1363281-27-9
Chemical Name
VU 0409551
Synonyms
VU 0409551;JNJ-46778212;JNJ 46778212,JNJ46778212;JNJ-46778212, 10 mM in DMSO;[6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone;(4-Fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone;(4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl]methanone;Methanone, [6,7-dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)-
CBNumber
CB33354233
Molecular Formula
C20H17FN2O3
Formula Weight
352.36
MOL File
1363281-27-9.mol
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VU 0409551 Property

Boiling point:
545.8±50.0 °C(Predicted)
Density 
1.308±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble; Ethanol: soluble
form 
A crystalline solid
pka
1.35±0.20(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2783
Product name
VU0409551
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$73.62
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2783
Product name
VU0409551
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$372.4
Updated
2025/07/31
Cayman Chemical
Product number
18042
Product name
VU0409551
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18042
Product name
VU0409551
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
18042
Product name
VU0409551
Packaging
10mg
Price
$169
Updated
2024/03/01
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VU 0409551 Chemical Properties,Usage,Production

Uses

VU 0409551 is an mGlu5 allosteric modulator.

Biological Activity

VU0409551 (JNJ-46778212) is an orally available, potent and selective biased metabotropic glutamate receptor subtype 5 positive allosteric modulator (mGlu5 PAM). VU0409551 (JNJ-46778212) selectively potentiates mGlu5 coupling to Gaq-mediated signaling without modulation of NMDAR currents in hippocampal neurons. VU0409551 exhibits potent antipsychotic-like and cognition enhancing activity in animal models.

in vivo

In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration[1]. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR?/? mice. The administration of JNJ-46778212 to SR?/? mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory[2].

IC 50

mGlu5 Receptor: 260 nM (EC50)

storage

Store at +4°C

VU 0409551 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU 0409551 Suppliers

China 34 United Kingdom 1 United States 6 Global 41
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

1363281-27-9, VU 0409551Related Search:


  • VU 0409551
  • JNJ-46778212
  • [6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone
  • (4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl]methanone
  • Methanone, [6,7-dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)-
  • JNJ 46778212,JNJ46778212
  • (4-Fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone
  • JNJ-46778212, 10 mM in DMSO
  • 1363281-27-9