4-(BROMOMETHYL)-2-FLUOROBENZONITRILE
- Product Name
- 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE
- CAS No.
- 222978-03-2
- Chemical Name
- 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE
- Synonyms
- 4-CYANO-3-FLUOROBENZYL BROMIDE;4-Cyano-3-fluorobenzylbromide98%;4-Cyano-3-fluorobenzyl bromide 98%;4-(BROMOMETHYL)-2-FLUOROBENZONITRILE;Benzonitrile, 4-(bromomethyl)-2-fluoro-;4-(Bromomethyl)-2-fluorobenzonitrile 98%;4-Cyano-3-fluorobenzyl bromide, alpha-Bromo-2-fluoro-p-tolunitrile
- CBNumber
- CB3339303
- Molecular Formula
- C8H5BrFN
- Formula Weight
- 214.03
- MOL File
- 222978-03-2.mol
4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Property
- Melting point:
- 44-45 °C
- Boiling point:
- 275.6±30.0 °C(Predicted)
- Density
- 1.59±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Methanol (Slightly)
- form
- Solid
- color
- Off-White
- Sensitive
- Lachrymatory
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B697158
- Product name
- 4-(Bromomethyl)-2-fluorobenzonitrile
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- B697158
- Product name
- 4-(Bromomethyl)-2-fluorobenzonitrile
- Packaging
- 10g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- PC5928
- Product name
- 4-(Bromomethyl)-2-fluorobenzonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $38
- Updated
- 2021/12/16
- Product number
- 3737-B-X0
- Product name
- 4-Cyano-3-fluorobenzyl bromide
- Purity
- 98%
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- FC37300
- Product name
- 4-Cyano-3-fluorobenzyl bromide
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Chemical Properties,Usage,Production
Uses
4-(Bromomethyl)-2-fluorobenzonitrile is a useful building block for the preparation and optimization of the highly selective GLUT1 inhibitor, BAY-876.
Synthesis
85070-67-3
222978-03-2
2-Fluoro-4-methylbenzonitrile (10 g, 74.07 mmol) was used as a raw material, which was dissolved in 200 mL of chloroform, 1 g of benzoyl peroxide (BPO) was added, and stirred until completely dissolved. Subsequently, N-bromosuccinimide (NBS, 19.77 g, 11.11 mmol) was added in batches and the reaction mixture was refluxed for 12 hours. After completion of the reaction, it was cooled to room temperature and washed three times with saturated aqueous sodium bicarbonate solution, then three times with appropriate amount of water and finally three times with saturated brine. The solvent was removed by evaporation under reduced pressure and purified by column chromatography to give the light yellow liquid product 4-cyano-3-fluorobenzyl bromide (14.00 g) in 88.79% yield.
References
[1] Patent: CN106810552, 2017, A. Location in patent: Paragraph 0068; 0070; 0071
[2] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1325 - 1344
[3] Organic and Biomolecular Chemistry, 2004, vol. 2, # 9, p. 1339 - 1352
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 20, p. 2925 - 2930
[5] Journal of the American Chemical Society, 2001, vol. 123, # 9, p. 2107 - 2108
4-(BROMOMETHYL)-2-FLUOROBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE manufacturers
- Product
- 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE 222978-03-2
- Price
- US $101.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-28