ChemicalBook > CAS DataBase List > 3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol

3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol

Product Name
3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol
CAS No.
315702-75-1
Chemical Name
3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol
Synonyms
KCC-07;KCC-07, 10 mM in DMSO;3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol;3-((4-(Pyridin-2-yl)thiazol-2-yl)amino)phenol;Phenol, 3-[[4-(2-pyridinyl)-2-thiazolyl]amino]-;3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol;KCC07,BAI1,p53,inhibit,ADGRB1,anticancer,Inhibitor,DNA Alkylator/Crosslinker,MBD2,KCC-07,anti-proliferative,ADGR,KCC 07,brain-penetrant
CBNumber
CB33680332
Molecular Formula
C14H11N3OS
Formula Weight
269.32
MOL File
315702-75-1.mol
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3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol Property

Boiling point:
497.7±55.0 °C(Predicted)
Density 
1.380±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
Soluble in DMSO
pka
9.55±0.10(Predicted)
form 
Solid
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
6615
Product name
KCC07
Purity
≥98%(HPLC)
Packaging
10
Price
$156
Updated
2021/12/16
Tocris
Product number
6615
Product name
KCC07
Purity
≥98%(HPLC)
Packaging
50
Price
$654
Updated
2021/12/16
TRC
Product number
K145558
Product name
KCC07
Packaging
1mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0120742
Product name
KCC-07
Purity
99.26%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0120742
Product name
KCC-07
Purity
99.26%
Packaging
25mg
Price
$300
Updated
2021/12/16
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3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol Chemical Properties,Usage,Production

Uses

KCC 07 is a MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.

Biological Activity

KCC-07 is a brain penetrant, potent and selective inhibitor of MBD2 (methyl-CpG-binding domain protein 2) th at inhibits binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. KCC-07 inhibits medulloblastoma cell proliferation, and inhibits tumor growth in mice xenograft models of medulloblastoma.

in vivo

KCC-07 (100 mg/kg; intraperitoneal injection; 5 days/week; athymic nude mice) treatment inhibits tumor growth and significantly extends the survival of MB xenografts in vivo[1].

Animal Model:Outbred athymic nude mice (females; 8-10 weeks old) injected with MB cells[1]
Dosage:100 mg/kg
Administration:Intraperitoneal injection; 5 days/week
Result:Significantly extended the survival of MB xenografts in vivo.

storage

Store at +4°C

3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol Suppliers

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315702-75-1, 3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenolRelated Search:


  • 3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol
  • 3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol
  • KCC-07
  • 3-((4-(Pyridin-2-yl)thiazol-2-yl)amino)phenol
  • KCC07,BAI1,p53,inhibit,ADGRB1,anticancer,Inhibitor,DNA Alkylator/Crosslinker,MBD2,KCC-07,anti-proliferative,ADGR,KCC 07,brain-penetrant
  • Phenol, 3-[[4-(2-pyridinyl)-2-thiazolyl]amino]-
  • KCC-07, 10 mM in DMSO
  • 315702-75-1