3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol
- Product Name
- 3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol
- CAS No.
- 315702-75-1
- Chemical Name
- 3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol
- Synonyms
- KCC-07;KCC-07, 10 mM in DMSO;3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol;3-((4-(Pyridin-2-yl)thiazol-2-yl)amino)phenol;Phenol, 3-[[4-(2-pyridinyl)-2-thiazolyl]amino]-;3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol;KCC07,BAI1,p53,inhibit,ADGRB1,anticancer,Inhibitor,DNA Alkylator/Crosslinker,MBD2,KCC-07,anti-proliferative,ADGR,KCC 07,brain-penetrant
- CBNumber
- CB33680332
- Molecular Formula
- C14H11N3OS
- Formula Weight
- 269.32
- MOL File
- 315702-75-1.mol
3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol Property
- Boiling point:
- 497.7±55.0 °C(Predicted)
- Density
- 1.380±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in DMSO
- pka
- 9.55±0.10(Predicted)
- form
- Solid
- color
- White to yellow
N-Bromosuccinimide Price
- Product number
- 6615
- Product name
- KCC07
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $156
- Updated
- 2021/12/16
- Product number
- 6615
- Product name
- KCC07
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $654
- Updated
- 2021/12/16
- Product number
- K145558
- Product name
- KCC07
- Packaging
- 1mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0120742
- Product name
- KCC-07
- Purity
- 99.26%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0120742
- Product name
- KCC-07
- Purity
- 99.26%
- Packaging
- 25mg
- Price
- $300
- Updated
- 2021/12/16
3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol Chemical Properties,Usage,Production
Uses
KCC 07 is a MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.
Biological Activity
KCC-07 is a brain penetrant, potent and selective inhibitor of MBD2 (methyl-CpG-binding domain protein 2) th at inhibits binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. KCC-07 inhibits medulloblastoma cell proliferation, and inhibits tumor growth in mice xenograft models of medulloblastoma.
in vivo
KCC-07 (100 mg/kg; intraperitoneal injection; 5 days/week; athymic nude mice) treatment inhibits tumor growth and significantly extends the survival of MB xenografts in vivo[1].
| Animal Model: | Outbred athymic nude mice (females; 8-10 weeks old) injected with MB cells[1] |
| Dosage: | 100 mg/kg |
| Administration: | Intraperitoneal injection; 5 days/week |
| Result: | Significantly extended the survival of MB xenografts in vivo. |
storage
Store at +4°C
3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol Preparation Products And Raw materials
Raw materials
Preparation Products
3-{[4-(pyridin-2-yl)-1,3-thiazol-2-yl]amino}phenol Suppliers
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