ChemicalBook > CAS DataBase List > 3-Carboxyphenylboronic acid

3-Carboxyphenylboronic acid

Product Name
3-Carboxyphenylboronic acid
CAS No.
25487-66-5
Chemical Name
3-Carboxyphenylboronic acid
Synonyms
3-BORONOBENZOIC ACID;m-carboxybenzeneboronicacid;AKOS BRN-0007;"25487-66-5 ";3-CarboxyphenyL;3-borono-benzoicaci;RARECHEM AH PB 0148;m-borono-benzoicaci;3-Carboxyphenylboron;Benzoic acid, 3-borono-
CBNumber
CB3376096
Molecular Formula
C7H7BO4
Formula Weight
165.94
MOL File
25487-66-5.mol
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3-Carboxyphenylboronic acid Property

Melting point:
243-247 °C (lit.)
Boiling point:
434.5±47.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka
4.21±0.10(Predicted)
form 
Crystalline Powder
color 
Off-white
Water Solubility 
2.5 g/100 mL
BRN 
2967400
InChI
InChI=1S/C7H7BO4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4,11-12H,(H,9,10)
InChIKey
DBVFWZMQJQMJCB-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=CC(B(O)O)=C1
CAS DataBase Reference
25487-66-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
37/39-26-36
WGK Germany 
2
RTECS 
CY8750000
HazardClass 
IRRITANT
HS Code 
29163990
Toxicity
mouse,LD50,intravenous,2560mg/kg (2560mg/kg),"Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964Vol. -, Pg. 693, 1964.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
456764
Product name
3-Carboxyphenylboronic acid
Purity
≥95%
Packaging
1g
Price
$52.12
Updated
2025/07/31
Sigma-Aldrich
Product number
456764
Product name
3-Carboxyphenylboronic acid
Purity
≥95%
Packaging
10g
Price
$67.35
Updated
2025/07/31
TCI Chemical
Product number
C2028
Product name
3-Carboxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
C2028
Product name
3-Carboxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$109
Updated
2025/07/31
Strem Chemicals
Product number
05-0399
Product name
3-Carboxyphenylboronic acid, min. 97%
Packaging
1g
Price
$62
Updated
2024/03/01
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3-Carboxyphenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

3-Carboxyphenylboronic acid is off-white crystalline powder

Uses

suzuki reaction

Uses

3-Carboxyphenylboronic acid can be used as a substrate in the preparation of:

  • Biaryl derivatives by reacting with bromoaniline through the Suzuki-Miyaura coupling reaction.
  • Boronic acid-functionalized block copolymer.
  • 1H-Imidazo[1,2-a]quinoxaline derivatives.

Uses

3-Carboxyphenylboronic acid is used in Suzuki coupling chemistry.1,2,3

Synthesis

150255-96-2

25487-66-5

1. Synthesis of 3-carboxyphenylboronic acid: 10 g (68 mmol) of 3-cyanophenylboronic acid was suspended in 40 mL of ethylene glycol with 15.26 g (272 mmol, 4 eq.) of potassium hydroxide powder, heated to 175 °C and maintained for 3 hours. After completion of the reaction, the reaction mixture was cooled and diluted with 60 mL of water. The pH was adjusted to 2-3 with 32% hydrochloric acid solution, colorless crystalline 3-carboxyphenylboronic acid was precipitated and the product was separated by filtration. The resulting crystals were washed with water and dried under mild vacuum at 35 °C. The final product was 10.04 g in mass. The final product was 10.04 g (60.5 mmol, 89% yield).

References

[1] Patent: US2009/286995, 2009, A1. Location in patent: Page/Page column 4

3-Carboxyphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

3-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 3-(3-PYRIDINYL)BENZOIC ACID
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View Lastest Price from 3-Carboxyphenylboronic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
3-Carboxyphenylboronic acid 25487-66-5
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-25
Hebei Zhuanglai Chemical Trading Co Ltd
Product
3-Carboxyphenylboronic acid 25487-66-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-28
Hebei Chuanghai Biotechnology Co,.LTD
Product
3-Carboxyphenylboronic acid 25487-66-5
Price
US $9.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
1 ton
Release date
2024-08-19

25487-66-5, 3-Carboxyphenylboronic acidRelated Search:

4-Formylbenzoic acid 2-Carboxybenzaldehyde Phenylboronic acid Ethyl 2-(Chlorosulfonyl)acetate Glycine Folic acid Carboxy styrene-butadiene latex 4-Carboxyphenylboronic acid 4-Hydroxyphenylboronic acid 3-AMINO-5-METHOXYCARBONYLPHENYLBORONIC ACID, HCL 3-Ethoxycarbonylphenylboronic acid 3-(ISOPROPOXYCARBONYL)PHENYLBORONIC ACID 3-METHOXYCARBONYL-5-NITROPHENYLBORONIC ACID 2,4-Dimethoxybenzeneboronic acid ETHYL 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE 3-tert-Butoxycarbonylphenylboronic acid (3-ETHOXYCARBONYL-5-NITROPHENYL)BORONIC ACID 3-Methoxycarbonylphenylboronic acid pinacol ester

  • 3-(dihydroxyboranyl)benzoic acid
  • 3 - carboxyl benzene boric acid
  • RARECHEM AH PB 0148
  • 3-borono-benzoicaci
  • 3-Carboxypenylboronic Acid
  • m-borono-benzoicaci
  • m-carboxy-benzeneboronicaci
  • m-carboxybenzeneboronicacid
  • M-CARBOXYPHENYLBORONIC ACID
  • AKOS BRN-0007
  • 3-BORONOBENZOIC ACID
  • 3-CARBOXYBENZENEBORONIC ACID
  • 3-CARBOXYPHENYLBORONIC ACID
  • 3-(DIHYDROXYBORYL)BENZOIC ACID
  • 3-(DIHYDROXYBORANE)BENZOIC ACID
  • 3-(DIHYDROXYBORONYL)BENZOIC ACID
  • 3-Carboxyphenylboronicacid,min.97%
  • 3-CARBOXYBENZENEBORONIC ACID 98%
  • 3-Carboxyphenylboronic Acid (contains varying amounts of Anhydride)
  • 3-Carboxyphenylboronic acid ,98%
  • 3-Carboxyphenylboronic acid, min. 97%
  • (3-Formyloxyphenyl)boronicacid
  • 3-Carboxyphenylboron
  • 3-(dihydroxyboryl)benzoic acid(SALTDATA: FREE)
  • 3-Carboxyphenylboronic acid, 98% 5GR
  • "25487-66-5 "
  • 3-Carboxyphenylboronic acid Eltrombopag Lumacaftor
  • 3-CarboxyphenyL
  • Benzoic acid, 3-borono-
  • 3-Carboxyphenylboronic acid 25487-66-5
  • 3-Carboxybenzeneboronic Acid extrapure, 97%
  • Eltrombopag Impurity 31
  • Benzeneboronic acid, m-carboxy-
  • 3-Carboxyphenylboronic acid, 97%
  • 3-Carboxyphenylboronic acid - [C2160]
  • 25487-66-5
  • 25487-66-6
  • C7H7BO4
  • HO2CC6H4BOH2
  • HOOCC6H4BOH2
  • BORONIC ACID
  • B (Classes of Boron Compounds)
  • Boronic Acids
  • Boronic Acids and Derivatives
  • Aryl
  • Organometallic Reagents
  • Substituted Boronic Acids
  • B (Classes of Boron Compounds)
  • CHIRAL CHEMICALS
  • Boronic Acids & Esters
  • Phenyls & Phenyl-Het
  • Boronic Acids
  • Boronic Acids and Derivatives
  • organic or inorganic borate
  • Boronic Acids & Esters
  • Phenyls & Phenyl-Het
  • Boronic acids
  • Boronic Acid