Alamandine
- Product Name
- Alamandine
- CAS No.
- 1176306-10-7
- Chemical Name
- Alamandine
- Synonyms
- Alamandine;Angiotensin A (1-7);Angiotensin A (1-7) trifluoroacetate;L-Alanyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline;L-Proline, L-alanyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-;Angiotensin A (1-7) trifluoroacetate salt H-Ala-Arg-Val-Tyr-Ile-His-Pro-OH trifluoroacetate salt
- CBNumber
- CB34668988
- Molecular Formula
- C40H62N12O9
- Formula Weight
- 855
- MOL File
- 1176306-10-7.mol
Alamandine Property
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 3.28±0.20(Predicted)
- color
- White to off-white
- Sequence
- Ala-Arg-Val-Tyr-Ile-His-Pro
N-Bromosuccinimide Price
- Product number
- SML1374
- Product name
- Alamandine trifluoroacetate salt
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $118
- Updated
- 2025/07/31
- Product number
- SML1374
- Product name
- Alamandine trifluoroacetate salt
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $462
- Updated
- 2025/07/31
- Product number
- CS-0145495
- Product name
- Alamandine
- Packaging
- 5mg
- Price
- $380
- Updated
- 2021/12/16
Alamandine Chemical Properties,Usage,Production
Uses
Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions[1][2].
Definition
ChEBI: Alamandine is a peptide.
Biochem/physiol Actions
Alamandine is an endogenous heptapeptide that can be formed from angiotensin A by angiotensin converting enzyme-2 or directly from angiotensin-(1–7) by decarboxylation of its aspartate residue. Alamandine′s activity is similar to Ang-(1–7) rather than that of angiotensin II or angiotensin A. However, Alamandine acts at a different receptor, the Mas-related receptor, MrgD. Alamandine causes vasodilation, and has antifibrosis and antihypertensive activity.
in vivo
Alamandine (0.15 ?μL/h; administered by mini-osmotic pumps; for 6 weeks) treatment ameliorates hypertension and impaires left ventricle (LV) function in SHRs. Also decreases the mass gains of heart and lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, and inhibits the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide[3].
| Animal Model: | Male spontaneously hypertensive rats (SHRs, 50-week-old)[3] |
| Dosage: | 0.15 ?μL/h (~50 μg/kg/day) |
| Administration: | Administered by mini-osmotic pumps; for 6 weeks |
| Result: | Attenuated hypertension, alleviated cardiac hypertrophy, and improved LV function. |
References
[1] Daniel C Villela, et al. Alamandine: a new member of the angiotensin family. Curr Opin Nephrol Hypertens. 2014 Mar;23(2):130-4. DOI:10.1097/01.mnh.0000441052.44406.92
[2] Johanna Schleifenbaum. Alamandine and Its Receptor MrgD Pair Up to Join the Protective Arm of the Renin-Angiotensin System. Front Med (Lausanne). 2019 Jun 11;6:107. DOI:10.3389/fmed.2019.00107
[3] Chi Liu, et al. Alamandine attenuates hypertension and cardiac hypertrophy in hypertensive rats. Amino Acids. 2018 Aug;50(8):1071-1081. DOI:10.1007/s00726-018-2583-x
Alamandine Preparation Products And Raw materials
Raw materials
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