IP7E

Product Name: IP7E
CAS No.: 500164-74-9
Chemical Name: IP7E
Synonyms: IP7E;IP7e, 10 mM in DMSO;Nurr1 Activator, IP7e;isoxazolo-pyridinone 7e;inhibit,IP7e,Inhibitor,orally,Nurr1,NF-kB,brain-penetrant;6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one;Isoxazolo[4,5-c]pyridin-4(5H)-one, 6-[4-[(2-methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-;6-{4-[(2-methoxyethoxy)methyl]phenyl}-5-methyl-3-phenyl-4H,5H-[1,2]oxazolo[4,5-c]pyridin-4-one
CBNumber: CB34732562
Molecular Formula: C23H22N2O4
Formula Weight: 390.43
MOL File: 500164-74-9.mol

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IP7E Property

storage temp.: Store at -20°C
solubility: DMSO: 100 mM; Ethanol: 20 mM, warmed
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29726
Product name: IP7e
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 29726
Product name: IP7e
Packaging: 5mg
Price: $356
Updated: 2024/03/01

Tocris

Product number: 5699
Product name: IP7e
Purity: ≥98%(HPLC)
Packaging: 10
Price: $184
Updated: 2021/12/16

Tocris

Product number: 5699
Product name: IP7e
Purity: ≥98%(HPLC)
Packaging: 50
Price: $774
Updated: 2021/12/16

Usbiological

Product number: 452435
Product name: IP7e
Packaging: 1mg
Price: $368
Updated: 2021/12/16

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IP7E Chemical Properties,Usage,Production

Uses

IP7e is an activator of Nurr1 signaling pathway.

Biological Activity

Cell permeable: yes', 'Primary Target
Nurr1/NR4A2

in vivo

IP7e (Isoxazolo-pyridinone 7e; 10 mg/kg; oral gavage; twice a day) preventive treatment reduces the incidence and the severity of a MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE). IP7e attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process^[2].

Animal Model:	Female C57BL/6J mice (6-8 week-old) with experimental autoimmune encephalomyelitis (EAE)^[2].
Dosage:	10 mg/kg
Administration:	Oral gavage; twice a day; preventive administration (before the disease onset) from 7 to 23 d.p.i. and therapeutic (after the disease onset) from 21 to 36 d.p.i.
Result:	Preventive administration delayed the onset and reduces the incidence and severity of EAE, and decreased neuroinflammatory and histopathological alterations in the spinal cord of treated EAE mice. On the contrary, the course of EAE was not influenced by the therapeutic administration.

IC 50

Nurr1/NR4A2

storage

Store at +4°C

IP7E Preparation Products And Raw materials

Raw materials

Preparation Products

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IP7E Suppliers

China 25 Japan 1 United Kingdom 1 United States 4 USA 1 Global 32

Bide Pharmatech Ltd.

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Beijing Bolide Biotechnology Co., Ltd.

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500164-74-9, IP7ERelated Search:

IP7E

6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one

6-{4-[(2-methoxyethoxy)methyl]phenyl}-5-methyl-3-phenyl-4H,5H-[1,2]oxazolo[4,5-c]pyridin-4-one

Isoxazolo[4,5-c]pyridin-4(5H)-one, 6-[4-[(2-methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-

isoxazolo-pyridinone 7e

inhibit,IP7e,Inhibitor,orally,Nurr1,NF-kB,brain-penetrant

IP7e, 10 mM in DMSO

Nurr1 Activator, IP7e

500164-74-9