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IP7E

Product Name
IP7E
CAS No.
500164-74-9
Chemical Name
IP7E
Synonyms
IP7E;IP7e, 10 mM in DMSO;Nurr1 Activator, IP7e;isoxazolo-pyridinone 7e;inhibit,IP7e,Inhibitor,orally,Nurr1,NF-kB,brain-penetrant;6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one;Isoxazolo[4,5-c]pyridin-4(5H)-one, 6-[4-[(2-methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-;6-{4-[(2-methoxyethoxy)methyl]phenyl}-5-methyl-3-phenyl-4H,5H-[1,2]oxazolo[4,5-c]pyridin-4-one
CBNumber
CB34732562
Molecular Formula
C23H22N2O4
Formula Weight
390.43
MOL File
500164-74-9.mol
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IP7E Property

storage temp. 
Store at -20°C
solubility 
DMSO: 100 mM; Ethanol: 20 mM, warmed
form 
A solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29726
Product name
IP7e
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
29726
Product name
IP7e
Packaging
5mg
Price
$356
Updated
2024/03/01
Tocris
Product number
5699
Product name
IP7e
Purity
≥98%(HPLC)
Packaging
10
Price
$184
Updated
2021/12/16
Tocris
Product number
5699
Product name
IP7e
Purity
≥98%(HPLC)
Packaging
50
Price
$774
Updated
2021/12/16
Usbiological
Product number
452435
Product name
IP7e
Packaging
1mg
Price
$368
Updated
2021/12/16
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IP7E Chemical Properties,Usage,Production

Uses

IP7e is an activator of Nurr1 signaling pathway.

Biological Activity

Cell permeable: yes', 'Primary Target
Nurr1/NR4A2

in vivo

IP7e (Isoxazolo-pyridinone 7e; 10 mg/kg; oral gavage; twice a day) preventive treatment reduces the incidence and the severity of a MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE). IP7e attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process[2].

Animal Model:Female C57BL/6J mice (6-8 week-old) with experimental autoimmune encephalomyelitis (EAE)[2].
Dosage:10 mg/kg
Administration:Oral gavage; twice a day; preventive administration (before the disease onset) from 7 to 23 d.p.i. and therapeutic (after the disease onset) from 21 to 36 d.p.i.
Result:Preventive administration delayed the onset and reduces the incidence and severity of EAE, and decreased neuroinflammatory and histopathological alterations in the spinal cord of treated EAE mice. On the contrary, the course of EAE was not influenced by the therapeutic administration.

IC 50

Nurr1/NR4A2

storage

Store at +4°C

IP7E Preparation Products And Raw materials

Raw materials

Preparation Products

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IP7E Suppliers

China 25 Japan 1 United Kingdom 1 United States 4 USA 1 Global 32
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80

500164-74-9, IP7ERelated Search:


  • IP7E
  • 6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one
  • 6-{4-[(2-methoxyethoxy)methyl]phenyl}-5-methyl-3-phenyl-4H,5H-[1,2]oxazolo[4,5-c]pyridin-4-one
  • Isoxazolo[4,5-c]pyridin-4(5H)-one, 6-[4-[(2-methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-
  • isoxazolo-pyridinone 7e
  • inhibit,IP7e,Inhibitor,orally,Nurr1,NF-kB,brain-penetrant
  • IP7e, 10 mM in DMSO
  • Nurr1 Activator, IP7e
  • 500164-74-9