Etrasimod arginine

Etrasimod arginine Property

storage temp. 

-10 to -25°C

solubility 

DMSO: 2mg/mL, clear (Warmed)

form 

powder

color 

white to beige

InChIKey

GVPVVOSNDUAUKM-MRIOYIRHNA-N

SMILES

C([C@H](N)C(=O)O)CCNC(N)=N.C([C@H]1CCC2C3=CC(OCC4C=CC(C5CCCC5)=C(C(F)(F)F)C=4)=CC=C3NC1=2)C(=O)O |&1:1,13,r|

Hazard and Precautionary Statements (GHS)

Etrasimod arginine Chemical Properties,Usage,Production

Uses

Etrasimod arginine is an orally available S1P receptor modulator that is a potent full agonist of the S1P1 receptor and has partial agonist activity at S1P4. Etrasimod arginine reduces inflammation in a CD4+CD45RBhigh T cell-transferred mouse colitis model[1].

Biological Activity

Etrasimod arginine is an orally available, potent, and selective agonist of Sphingosine-1-Phosphate Receptors 1 (S1PR1). Also, it acts as a partial agonist of S1PR4,5. Etrasimod arginine induces reductions in lymphocyte counts in mice. It is acting as immunosuppressive agents.

References

[1] Etrasimod arginine. Sphingosine-1-phosphate receptor 1 (S1P1 receptor) agonist, Treatment of ulcerative colitis