2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
- Product Name
- 2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
- CAS No.
- 651005-90-2
- Chemical Name
- 2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
- Synonyms
- Jedi2;Compound Fr13138;Jedi2, 10 mM in DMSO;2-Methyl-5-(2-thienyl)-3-furancarboxylic acid;3-Furancarboxylic acid, 2-methyl-5-(2-thienyl)-
- CBNumber
- CB34902758
- Molecular Formula
- C10H8O3S
- Formula Weight
- 208.23
- MOL File
- 651005-90-2.mol
2-Methyl-5-(2-thienyl)-3-furancarboxylic acid Property
- Boiling point:
- 356.9±42.0 °C(Predicted)
- Density
- 1.336±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- powder
- pka
- 4.38±0.26(Predicted)
- color
- White
Safety
- HS Code
- 2932190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML2532
- Product name
- Jedi2
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $99.75
- Updated
- 2025/07/31
- Product number
- SML2532
- Product name
- Jedi2
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $406
- Updated
- 2025/07/31
- Product number
- PH017256
- Product name
- 2-Methyl-5-(2-thienyl)-3-furoic acid
- Purity
- AldrichCPR
- Packaging
- 500MG
- Price
- $99.7
- Updated
- 2023/06/20
- Product number
- 6614
- Product name
- Jedi2
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $590
- Updated
- 2021/12/16
- Product number
- 6614
- Product name
- Jedi2
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $141
- Updated
- 2021/12/16
2-Methyl-5-(2-thienyl)-3-furancarboxylic acid Chemical Properties,Usage,Production
Uses
Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770??μM[1].
Definition
ChEBI: 2-Methyl-5-(2-thienyl)-3-furoic acid is a furoic acid.
Biological Activity
Jedi2 is an activator of the mechanosensitive Piezo1 channel th at binds at a different place from Yoda1. It exhibits long-range allosteric gating, activating Piezo1 through the extracellular side of its peripheral blade-like structure rather than the C-terminal extracellular domain of the pore.
storage
Store at +4°C
References
[1] Yanfeng Wang, et al. A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat Commun. 2018 Apr 3;9(1):1300. DOI:10.1038/s41467-018-03570-9
2-Methyl-5-(2-thienyl)-3-furancarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Methyl-5-(2-thienyl)-3-furancarboxylic acid Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77