ChemicalBook > CAS DataBase List > N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide

N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide

Product Name
N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
CAS No.
223749-46-0
Chemical Name
N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
Synonyms
HMR 1556;HMR-1556 >=98% (HPLC);N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide;Methanesulfonamide, N-[(3R,4S)-3,4-dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methyl-
CBNumber
CB34902859
Molecular Formula
C17H24F3NO5S
Formula Weight
411.44
MOL File
223749-46-0.mol
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N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide Property

Melting point:
178-179 °C
Boiling point:
469.0±55.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
13.30±0.60(Predicted)
form 
Solid
color 
White to off-white
optical activity
[α]/D +2 to +3.5°, c =0.1 in methanol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2354
Product name
HMR-1556
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$121
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2354
Product name
HMR-1556
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$489
Updated
2025/07/31
Tocris
Product number
5011
Product name
HMR1556
Purity
≥98%(HPLC)
Packaging
10
Price
$227
Updated
2021/12/16
TRC
Product number
H456375
Product name
HMR1556
Packaging
50mg
Price
$800
Updated
2021/12/16
Usbiological
Product number
255458
Product name
HMR 1556
Packaging
10mg
Price
$480
Updated
2021/12/16
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N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide Chemical Properties,Usage,Production

Uses

HMR 1556 is an inhibitor of the slow delayed rectifier potassium current, used in the monitoring and treatment of proarrythmia.

Biological Activity

HMR-1556 is a potent and selective blocker of the heteromeric KCNQ1-KCNE1 (KvLQT1-MinK) voltage-gated channel-mediated slowly activating K+ current (IKs IC50 = 120 nM in hKCNE1-transfected Xenopus oocytes; little or no inhibition of Herg, Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kir2.1 (KCNJ2), HCN2 (BCNG2) current in respective oocyte transfectants). HMR-1556 is more potent than chromanol 293B (IKs IC50 = 34 nM and 2.1 μM, respectively; guinea pig ventricular myocytes), being inefficient against L-type Ca2+ channel or rapidly delayed & inward rectifier currents (IKr & IK1) in guinea pig ventricular myocytes, nor transient & sustained outward currents, I(to) & I(sus), in r at ventricular myocytes.

storage

Store at RT

N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide Suppliers

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223749-46-0, N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamideRelated Search:


  • HMR 1556
  • N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
  • Methanesulfonamide, N-[(3R,4S)-3,4-dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methyl-
  • HMR-1556 >=98% (HPLC)
  • 223749-46-0
  • C17H24F3NO5S