N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide

Product Name: N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
CAS No.: 223749-46-0
Chemical Name: N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
Synonyms: HMR 1556;HMR-1556 >=98% (HPLC);N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide;Methanesulfonamide, N-[(3R,4S)-3,4-dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methyl-
CBNumber: CB34902859
Molecular Formula: C17H24F3NO5S
Formula Weight: 411.44
MOL File: 223749-46-0.mol

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N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide Property

Melting point:: 178-179 °C
Boiling point:: 469.0±55.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 13.30±0.60(Predicted)
form: Solid
color: White to off-white
optical activity: [α]/D +2 to +3.5°, c =0.1 in methanol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2354
Product name: HMR-1556
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $121
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2354
Product name: HMR-1556
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $489
Updated: 2025/07/31

Tocris

Product number: 5011
Product name: HMR1556
Purity: ≥98%(HPLC)
Packaging: 10
Price: $227
Updated: 2021/12/16

TRC

Product number: H456375
Product name: HMR1556
Packaging: 50mg
Price: $800
Updated: 2021/12/16

Usbiological

Product number: 255458
Product name: HMR 1556
Packaging: 10mg
Price: $480
Updated: 2021/12/16

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N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide Chemical Properties,Usage,Production

Uses

HMR 1556 is an inhibitor of the slow delayed rectifier potassium current, used in the monitoring and treatment of proarrythmia.

Biological Activity

HMR-1556 is a potent and selective blocker of the heteromeric KCNQ1-KCNE1 (KvLQT1-MinK) voltage-gated channel-mediated slowly activating K+ current (IKs IC50 = 120 nM in hKCNE1-transfected Xenopus oocytes; little or no inhibition of Herg, Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kir2.1 (KCNJ2), HCN2 (BCNG2) current in respective oocyte transfectants). HMR-1556 is more potent than chromanol 293B (IKs IC50 = 34 nM and 2.1 μM, respectively; guinea pig ventricular myocytes), being inefficient against L-type Ca2+ channel or rapidly delayed & inward rectifier currents (IKr & IK1) in guinea pig ventricular myocytes, nor transient & sustained outward currents, I(to) & I(sus), in r at ventricular myocytes.

storage

Store at RT

N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide Suppliers

China 24 United Kingdom 1 United States 4 USA 1 Global 30

Shanghai EFE Biological Technology Co., Ltd.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Suzhou Meishi Biotechnology Co., Ltd.

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223749-46-0, N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamideRelated Search:

HMR 1556

N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide

Methanesulfonamide, N-[(3R,4S)-3,4-dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methyl-

HMR-1556 >=98% (HPLC)

223749-46-0

C17H24F3NO5S