N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
- Product Name
- N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
- CAS No.
- 223749-46-0
- Chemical Name
- N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
- Synonyms
- HMR 1556;HMR-1556 >=98% (HPLC);N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide;Methanesulfonamide, N-[(3R,4S)-3,4-dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methyl-
- CBNumber
- CB34902859
- Molecular Formula
- C17H24F3NO5S
- Formula Weight
- 411.44
- MOL File
- 223749-46-0.mol
N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide Property
- Melting point:
- 178-179 °C
- Boiling point:
- 469.0±55.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 13.30±0.60(Predicted)
- form
- Solid
- color
- White to off-white
- optical activity
- [α]/D +2 to +3.5°, c =0.1 in methanol
N-Bromosuccinimide Price
- Product number
- SML2354
- Product name
- HMR-1556
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $121
- Updated
- 2025/07/31
- Product number
- SML2354
- Product name
- HMR-1556
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $489
- Updated
- 2025/07/31
- Product number
- 5011
- Product name
- HMR1556
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $227
- Updated
- 2021/12/16
- Product number
- 255458
- Product name
- HMR 1556
- Packaging
- 10mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- H456375
- Product name
- HMR1556
- Packaging
- 50mg
- Price
- $800
- Updated
- 2021/12/16
N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide Chemical Properties,Usage,Production
Uses
HMR 1556 is an inhibitor of the slow delayed rectifier potassium current, used in the monitoring and treatment of proarrythmia.
Biological Activity
HMR-1556 is a potent and selective blocker of the heteromeric KCNQ1-KCNE1 (KvLQT1-MinK) voltage-gated channel-mediated slowly activating K+ current (IKs IC50 = 120 nM in hKCNE1-transfected Xenopus oocytes; little or no inhibition of Herg, Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kir2.1 (KCNJ2), HCN2 (BCNG2) current in respective oocyte transfectants). HMR-1556 is more potent than chromanol 293B (IKs IC50 = 34 nM and 2.1 μM, respectively; guinea pig ventricular myocytes), being inefficient against L-type Ca2+ channel or rapidly delayed & inward rectifier currents (IKr & IK1) in guinea pig ventricular myocytes, nor transient & sustained outward currents, I(to) & I(sus), in r at ventricular myocytes.
storage
Store at RT
N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide Suppliers
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