ChemicalBook > CAS DataBase List > tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate

tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate

Product Name
tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate
CAS No.
939681-36-4
Chemical Name
tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate
Synonyms
G5-7;G5-7 ，E0793;G5-7, 10 mM in DMSO;JAK2 inhibitor 5-7;tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3,5-bis[(2-fluorophenyl)methylene]-4-oxo-, ethyl ester;antiangiogenic,inhibit,Apoptosis,JAK,Glioma,G-5-7,cycle,G5 7,phase,G57,STAT3,cell,Inhibitor,EGFR,Janus kinase,G5-7,mTOR
CBNumber
CB35438865
Molecular Formula
C22H19F2NO3
Formula Weight
383.39
MOL File
939681-36-4.mol
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tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate Property

storage temp. 
Store at -20°C
solubility 
DMSO : 83.33 mg/mL (217.35 mM; Need ultrasonic)
form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0086991
Product name
G5-7
Purity
99.84%
Packaging
5mg
Price
$200
Updated
2021/12/16
ChemScene
Product number
CS-0086991
Product name
G5-7
Purity
99.84%
Packaging
10mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0086991
Product name
G5-7
Purity
99.84%
Packaging
25mg
Price
$550
Updated
2021/12/16
Ambeed
Product number
A253292
Product name
tert-Butyl3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate
Purity
98+%
Packaging
25mg
Price
$589
Updated
2021/12/16
Ambeed
Product number
A253292
Product name
tert-Butyl3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate
Purity
98+%
Packaging
50mg
Price
$882
Updated
2021/12/16
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tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

G5-7, an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. G5-7 has the potential for glioma study[1].

in vivo

G5-7 (10 and 50 mg/kg, oral gavege) decreases VEGF secretion and exerts a potent antiangiogenic effect[1].

Animal Model:Cells (4 × 106) in 100 μl of serum-free DMEM were inoculated subcutaneously into 5- to 6-week-old female nude mice[1].
Dosage:10 and 50 mg/kg.
Administration:Oral gavage.
Result:Suppresses angiogenesis in tumors.

IC 50

JAK2

References

[1] Kunyan He, et al. Blockade of glioma proliferation through allosteric inhibition of JAK2. Sci Signal. 2013 Jul 9;6(283):ra55. DOI:10.1126/scisignal.2003900

tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate Suppliers

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939681-36-4, tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylateRelated Search:


  • tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate
  • 1-Piperidinecarboxylic acid, 3,5-bis[(2-fluorophenyl)methylene]-4-oxo-, ethyl ester
  • G5-7
  • antiangiogenic,inhibit,Apoptosis,JAK,Glioma,G-5-7,cycle,G5 7,phase,G57,STAT3,cell,Inhibitor,EGFR,Janus kinase,G5-7,mTOR
  • JAK2 inhibitor 5-7
  • G5-7, 10 mM in DMSO
  • G5-7 ，E0793
  • 939681-36-4