Dual Specificity Protein Phosphatase 1/6 Inhibitor
- Product Name
- Dual Specificity Protein Phosphatase 1/6 Inhibitor
- CAS No.
- 15982-84-0
- Chemical Name
- Dual Specificity Protein Phosphatase 1/6 Inhibitor
- Synonyms
- NSC 150117;(E/Z)-BCI (NSC150117);(E/Z)-BCI, 10 mM in DMSO;(E/Z)-BCI(DUSP6 inhibitor);Dual Specificity Protein Phosphatase 1/6 Inhibitor;Dual Specificity Protein Phosphatase 1/6 Inhibitor, BCI;2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-;NSC-150117,ROS,death,LPS,(E/Z)-BCI,gastric cancer,anti-inflammatory,NF-κB,inhibit,Inhibitor,(E/Z) BCI,Nrf2,(E/Z)BCI,Apoptosis,ERK,Phosphatase,DUSP6,NSC150117
- CBNumber
- CB35544728
- Molecular Formula
- C22H23NO
- Formula Weight
- 317.42
- MOL File
- 15982-84-0.mol
Dual Specificity Protein Phosphatase 1/6 Inhibitor Property
- Boiling point:
- 484.6±45.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO: 63 mg/mL (198.48 mM);Ethanol: 20 mg/mL (63.01 mM)
- form
- solid
- pka
- 7.74±0.20(Predicted)
- color
- yellow
- Water Solubility
- Water: Insoluble
Safety
- HS Code
- 2922390090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BISN0086
- Product name
- BCI
- Purity
- 98%
- Packaging
- 1mg
- Price
- $211
- Updated
- 2021/12/16
- Product number
- BISN0086
- Product name
- BCI
- Purity
- 98%
- Packaging
- 5mg
- Price
- $385
- Updated
- 2021/12/16
- Product number
- BISN0086
- Product name
- BCI
- Purity
- 98%
- Packaging
- 10mg
- Price
- $617
- Updated
- 2021/12/16
- Product number
- A1145656
- Product name
- 2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one
- Purity
- 98%
- Packaging
- 1mg
- Price
- $41
- Updated
- 2021/12/16
- Product number
- A1145656
- Product name
- 2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one
- Purity
- 98%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
Dual Specificity Protein Phosphatase 1/6 Inhibitor Chemical Properties,Usage,Production
Uses
(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway[1].
in vivo
(E/Z)-BCI hydrochloride (35 mg/kg; intraperitoneal injection; every 7 days; for four weeks; female BALB/c nude mice) treatment enhances cisplatin efficacy in PDX models[2].
| Animal Model: | Patient-derived xenograft (PDX) models (4-5-week-old female BALB/c nude mice)[2] |
| Dosage: | 35 mg/kg |
| Administration: | Intraperitoneal injection; every 7 days; for four weeks |
| Result: | Tumor weights in the PDX models treated plus CDDP were significantly suppressed compared with tumors from PDX model mice treated with either agent alone. |
storage
Store at +4°C
References
[1] Zhang F, et al. DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42(2):672-681. DOI:10.1007/s10753-018-0924-2
[2] Wu QN,et al. Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance. Cancer Lett. 2018 Jan 1;412:243-255. DOI:10.1016/j.canlet.2017.10.007
Dual Specificity Protein Phosphatase 1/6 Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
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