1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel-
- Product Name
- 1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel-
- CAS No.
- 1446350-60-2
- Chemical Name
- 1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel-
- Synonyms
- TCH-16;TCH-165, 10 mM in DMSO;ethyl (4R,5R)-3-benzyl-4-[4-(benzylamino)phenyl]-2-(4-methoxyphenyl)-5-phenyl-4H-imidazole-5-carboxylate;rel-Ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate;Proteasome,tau,trypsin-like,20S,TCH165,IDPs,chymotrypsin-like,degradation,TCH 165,α-syn,inhibit,caspase-like,TCH-165,assembly,Inhibitor;1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel-
- CBNumber
- CB35562371
- Molecular Formula
- C39H37N3O3
- Formula Weight
- 595.73
- MOL File
- 1446350-60-2.mol
1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel- Property
- Boiling point:
- 724.6±70.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 250 mg/mL (419.65 mM)
- pka
- 7.15±0.70(Predicted)
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- SML3911
- Product name
- TCH-165
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $94.05
- Updated
- 2025/07/31
- Product number
- SML3911
- Product name
- TCH-165
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $399
- Updated
- 2025/07/31
- Product number
- CS-0078906
- Product name
- TCH-165
- Purity
- 99.31%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0078906
- Product name
- TCH-165
- Purity
- 99.31%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0078906
- Product name
- TCH-165
- Purity
- 99.31%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel- Chemical Properties,Usage,Production
Uses
TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation[1].
Biological Activity
Cell-permeable and potent activator of 20S proteasome assembly th at and enhances 20S-mediated proteolysis.
TCH-165 is a cell-permeable and potent activator of 20S proteasome assembly th at favors a proteolytically active, open-gate 20S proteasome subcomplex and enhances 20S-mediated proteolysis (nearly 10-fold ≤1.5 μM) to the detriment of the 26S proteasome, in a time- and dose-dependent manner. TCH-165 restores proteostasis and enhances degradation of intrinsically disordered proteins (IDPs) both in purified protein assays and in cell culture (α-synuclein, tau441, c-MYC, cFos, ornithine decarboxylase). TCH 165 degrades SNAP29 and syntaxin 17 and reduces autophagosome-lysosome fusion. TCH165 inhibits cancer cell proliferation, impedes in vivo tumor growth, and offers neuroprotection from distinct dipeptide repe at (DPR) protein toxicity and is well tolerated in vivo (in mice and in dogs) at therapeutic concentrations.
storage
Store at -20°C
References
[1] Njomen E, et al. Small Molecule Modulation of Proteasome Assembly. Biochemistry. 2018 Jul 17;57(28):4214-4224. DOI:10.1021/acs.biochem.8b00579
1H-Imidazole-4-carboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-4-phenyl-1-(phenylmethyl)-5-[4-[(phenylmethyl)amino]phenyl]-, ethyl ester, (4R,5R)-rel- Preparation Products And Raw materials
Raw materials
Preparation Products
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