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ROCK inhibitor-2

Product Name
ROCK inhibitor-2
CAS No.
1127308-52-4
Chemical Name
ROCK inhibitor-2
Synonyms
ROCK inhibitor-2, 10 mM in DMSO;(R)-N-(1-(3-Methoxyphenyl)ethyl)-4-(pyridin-4-yl)benzamide;Benzamide, N-[(1R)-1-(3-methoxyphenyl)ethyl]-4-(4-pyridinyl)-
CBNumber
CB35821283
Molecular Formula
C21H20N2O2
Formula Weight
332.4
MOL File
1127308-52-4.mol
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ROCK inhibitor-2 Property

Boiling point:
541.9±50.0 °C(Predicted)
Density 
1.145±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 250 mg/mL (752.11 mM)
pka
13.41±0.46(Predicted)
form 
Solid
color 
Light yellow to khaki
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0078809
Product name
ROCKinhibitor-2
Purity
99.59%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0078809
Product name
ROCKinhibitor-2
Purity
99.59%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0078809
Product name
ROCKinhibitor-2
Purity
99.59%
Packaging
25mg
Price
$990
Updated
2021/12/16
ChemScene
Product number
CS-0078809
Product name
ROCKinhibitor-2
Purity
99.59%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0078809
Product name
ROCKinhibitor-2
Purity
99.59%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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ROCK inhibitor-2 Chemical Properties,Usage,Production

Uses

ROCK inhibitor-2 (compound 6) is a selective dual inhibitor of ROCK1 and ROCK2, with IC50 values of 160 nM and 21 nM, respectively. ROCK inhibitor-2 inhibits pMYPT1 with IC50 of 75 nM. ROCK inhibitor-2 exhibits antitumor activity[1][2].

in vivo

ROCK inhibitor-2 (10 mg/kg*day, ip, 27 days) exhibits antitumor efficacy in U2OS xenograft mouse models[2].

Animal Model:U2OS xenograft mouse models[2]
Dosage:10 mg/kg*day
Administration:ip, 27 days
Result:Inhibited tumor growth.

IC 50

ROCK1: 160 nM (IC50); ROCK2: 21 nM (IC50)

References

[1] Hobson AD, et al. Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based DrugDesign. J Med Chem. 2018 Dec 27;61(24):11074-11100. DOI:10.1021/acs.jmedchem.8b01098
[2] Zhang W, et al., 3D-printing magnesium-polycaprolactone loaded with melatonin inhibits the development of osteosarcoma by regulating cell-in-cell structures. J Nanobiotechnology. 2021 Sep 4;19(1):263. DOI:10.1186/s12951-021-01012-1

ROCK inhibitor-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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ROCK inhibitor-2 Suppliers

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1127308-52-4, ROCK inhibitor-2Related Search:


  • Benzamide, N-[(1R)-1-(3-methoxyphenyl)ethyl]-4-(4-pyridinyl)-
  • (R)-N-(1-(3-Methoxyphenyl)ethyl)-4-(pyridin-4-yl)benzamide
  • ROCK inhibitor-2, 10 mM in DMSO
  • 1127308-52-4