ROCK inhibitor-2
- Product Name
- ROCK inhibitor-2
- CAS No.
- 1127308-52-4
- Chemical Name
- ROCK inhibitor-2
- Synonyms
- ROCK inhibitor-2, 10 mM in DMSO;(R)-N-(1-(3-Methoxyphenyl)ethyl)-4-(pyridin-4-yl)benzamide;Benzamide, N-[(1R)-1-(3-methoxyphenyl)ethyl]-4-(4-pyridinyl)-
- CBNumber
- CB35821283
- Molecular Formula
- C21H20N2O2
- Formula Weight
- 332.4
- MOL File
- 1127308-52-4.mol
ROCK inhibitor-2 Property
- Boiling point:
- 541.9±50.0 °C(Predicted)
- Density
- 1.145±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 250 mg/mL (752.11 mM)
- pka
- 13.41±0.46(Predicted)
- form
- Solid
- color
- Light yellow to khaki
N-Bromosuccinimide Price
- Product number
- CS-0078809
- Product name
- ROCKinhibitor-2
- Purity
- 99.59%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0078809
- Product name
- ROCKinhibitor-2
- Purity
- 99.59%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0078809
- Product name
- ROCKinhibitor-2
- Purity
- 99.59%
- Packaging
- 25mg
- Price
- $990
- Updated
- 2021/12/16
- Product number
- CS-0078809
- Product name
- ROCKinhibitor-2
- Purity
- 99.59%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CS-0078809
- Product name
- ROCKinhibitor-2
- Purity
- 99.59%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
ROCK inhibitor-2 Chemical Properties,Usage,Production
Uses
ROCK inhibitor-2 (compound 6) is a selective dual inhibitor of ROCK1 and ROCK2, with IC50 values of 160 nM and 21 nM, respectively. ROCK inhibitor-2 inhibits pMYPT1 with IC50 of 75 nM. ROCK inhibitor-2 exhibits antitumor activity[1][2].
in vivo
ROCK inhibitor-2 (10 mg/kg*day, ip, 27 days) exhibits antitumor efficacy in U2OS xenograft mouse models[2].
| Animal Model: | U2OS xenograft mouse models[2] |
| Dosage: | 10 mg/kg*day |
| Administration: | ip, 27 days |
| Result: | Inhibited tumor growth. |
IC 50
ROCK1: 160 nM (IC50); ROCK2: 21 nM (IC50)
References
[1] Hobson AD, et al. Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based DrugDesign. J Med Chem. 2018 Dec 27;61(24):11074-11100. DOI:10.1021/acs.jmedchem.8b01098
[2] Zhang W, et al., 3D-printing magnesium-polycaprolactone loaded with melatonin inhibits the development of osteosarcoma by regulating cell-in-cell structures. J Nanobiotechnology. 2021 Sep 4;19(1):263. DOI:10.1186/s12951-021-01012-1
ROCK inhibitor-2 Preparation Products And Raw materials
Raw materials
Preparation Products
ROCK inhibitor-2 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58