4-Nitrophthalimide

Product Name: 4-Nitrophthalimide
CAS No.: 89-40-7
Chemical Name: 4-Nitrophthalimide
Synonyms: 5-NITROISOINDOLINE-1,3-DIONE;5-NITROPHTHALIMIDE;AKOS B028733;4-Nitrophtalimide;4-NITROPHTHALIMIDE;4-nitro-phthalimid;4-Nirtophthalimide;P-NITRO-PHTHALIMIDE;PHTHALIMIDE, 4-NITRO-;4-Nitrophthalimide>
CBNumber: CB3681521
Molecular Formula: C8H4N2O4
Formula Weight: 192.13
MOL File: 89-40-7.mol

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4-Nitrophthalimide Property

Melting point:: 206 °C
Boiling point:: 328.09°C (rough estimate)
Density: 1.5513 (rough estimate)
refractive index: 1.4900 (estimate)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 7.79±0.20(Predicted)
color: Yellow powder
Water Solubility: <0.01 g/100 mL at 18 ºC
BRN: 180224
Stability:: Stable. Combustible. Incompatible with moisture, water, strong oxidising agents, strong bases.
InChIKey: ANYWGXDASKQYAD-UHFFFAOYSA-N
CAS DataBase Reference: 89-40-7(CAS DataBase Reference)
NIST Chemistry Reference: 4-Nitro-phthalimide(89-40-7)
EPA Substance Registry System: 4-Nitrophthalimide (89-40-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-36-24/25
WGK Germany: 3
RTECS: TI5625000
Hazard Note: Irritant
TSCA: Yes
HS Code: 29251900
Toxicity: mmo-sat 333 mg/plate EMMUEG 11(Suppl 12),1,88

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 332097
Product name: 4-Nitrophthalimide
Purity: 98%
Packaging: 5g
Price: $77.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 332097
Product name: 4-Nitrophthalimide
Purity: 98%
Packaging: 25g
Price: $327
Updated: 2024/03/01

TCI Chemical

Product number: N0247
Product name: 4-Nitrophthalimide
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $31
Updated: 2024/03/01

TCI Chemical

Product number: N0247
Product name: 4-Nitrophthalimide
Purity: >98.0%(HPLC)(T)
Packaging: 500g
Price: $300
Updated: 2024/03/01

Alfa Aesar

Product number: A12040
Product name: 4-Nitrophthalimide, 98%
Packaging: 5g
Price: $38.85
Updated: 2023/01/06

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4-Nitrophthalimide Chemical Properties,Usage,Production

Chemical Properties

slight yellow powder

Uses

4-Nitrophthalimide is used as intermediate of organic synthesis and fluorescent dyes, it can be used to produce azo dyes, luminol, etc. It can also be used to prepare 4-nitrophthalonitrile, 5-cyanophthalide and other drug intermediates.

Preparation

4-Nitrophthalimide is synthesized from phthalimide by nitration. Cool the fuming nitric acid to below 5°C, slowly add concentrated sulfuric acid dropwise, and control the temperature to 10-13°C. Plus phthalimide. Leave at room temperature overnight. Then, it was poured into ice water with stirring, and the precipitate was precipitated below 20°C. Filter, wash with water, dry, and then recrystallize from ethanol to obtain 4-nitrophthalimide with a yield of 60%.

General Description

Yellow powder.

Air & Water Reactions

4-Nitrophthalimide can be hydrolyzed. . Insoluble in water.

Reactivity Profile

A nitrated amine. Amines are combustible. The combustion of amines yields noxious NOx. REACTIVITY - Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.

Fire Hazard

Flash point data for 4-Nitrophthalimide are not available, however 4-Nitrophthalimide is probably combustible.

Safety Profile

Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx.

Synthesis

200 mL of sulfuric acid and 50 mL of fuming nitric acid were cooled on an ice bath and 40 g (0.272 mol) phthalimide was added in portions within 1-1.5 hours so as not to exceed the internal temperature beyond 10-15 ??C. The mixture was stirred over ice bath for half an hour and the internal temperature was raised to 35 ??C, and yellow particles were observed to dissolve. The mixture was stirred for an additional 1 hour, then cooled to 0 ??C again and poured onto 1 kg of ice water mixture. Yellow 4-nitrophthalonitrile precipitated, it was filtered and washed with water until the filtrate was neutral to blue litmus paper. It was crystallized from 850-900 mL of ethyl alcohol. Bright yellow crystals were filtered, washed with cold ethyl alcohol, and dried in a vacuum oven at 80-90 ??C.

4-Nitrophthalimide Preparation Products And Raw materials

Raw materials

Phthalimide Nitric acid

Preparation Products

4-Nitrophthalic acid 4-Nitrophthalic anhydride

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4-Nitrophthalimide Suppliers

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View Lastest Price from 4-Nitrophthalimide manufacturers

Asia Chem I and E (Jiangsu) Co Ltd

Product: 4-Nitrophthalimide 89-40-7
Price: US $25.12/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 99.00%HPLC
Supply Ability: 10tons/month
Release date: 2021-09-18

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Nitrophthalimide 89-40-7
Price: US $10.70/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-23

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Nitrophthalimide 89-40-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-08-16

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4-Nitrophthalimide,98%

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4-Nitrophthalimide ISO 9001：2015 REACH

4-NITRO PHTHALIMIDE/4-Nitrophthalimide

89-40-7

C8H4N2O4

Organic Building Blocks

Cyclic Imides

Building Blocks

Carbonyl Compounds

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

N

Stains and Dyes

Stains&Dyes, A to