4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE
- Product Name
- 4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE
- CAS No.
- 2963-77-1
- Chemical Name
- 4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE
- Synonyms
- AKOS BB-7980;ASISCHEM T31097;imidazol-CHEMBRDG-BB 4101671;TIMTEC-BB SBB000485;4-(2-Benzimidazolyl)aniline;4-(1H-Benzo[d]imidazol-2-yl);2-[p-Aminophenyl]benzimidazole;2-(p-Aminophenyl)benzimidazole;2-(4-Aminophenyl)benzimidazole
- CBNumber
- CB3685387
- Molecular Formula
- C13H11N3
- Formula Weight
- 209.25
- MOL File
- 2963-77-1.mol
4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE Property
- Melting point:
- 248.0 to 252.0 °C
- Boiling point:
- 466.3±47.0 °C(Predicted)
- Density
- 1.286±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 11.77±0.10(Predicted)
- color
- White to Light yellow to Light orange
- λmax
- 314nm(HCl aq.)(lit.)
Safety
- Hazard Codes
- Xi
- HS Code
- 2933.99.8290
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H318Causes serious eye damage
H330Fatal if inhaled
H335May cause respiratory irritation
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P308+P313IF exposed or concerned: Get medical advice/attention.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- R702587
- Product name
- 4-(1H-BENZIMIDAZOL-2-YL)ANILINE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
- Product number
- R702587
- Product name
- 4-(1H-BENZIMIDAZOL-2-YL)ANILINE
- Purity
- AldrichCPR
- Packaging
- 25MG
- Price
- $179
- Updated
- 2024/03/01
- Product number
- B5710
- Product name
- 4-(1H-Benzimidazol-2-yl)aniline
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $169
- Updated
- 2025/07/31
- Product number
- B5710
- Product name
- 4-(1H-Benzimidazol-2-yl)aniline
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $590
- Updated
- 2025/07/31
- Product number
- B502225
- Product name
- 4-(1H-Benzimidazol-2-yl)aniline
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of Medicinal Chemistry, 39, p. 3375, 1996 DOI: 10.1021/jm9600959
Synthesis
150-13-0
95-54-5
2963-77-1
The reaction was carried out with 4-aminobenzoic acid (5 g, 5.78 mmol) and o-phenylenediamine (3.9 g, 3.68 mmol) in polyphosphoric acid (12.5 g) with stirring at 200 °C for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into crushed ice. Subsequently, the precipitate was stirred in cold water. The pH was adjusted with ammonium hydroxide solution to 7. The solid product was collected by filtration and washed several times with methanol. Finally, the target compound 4-(1H-benzimidazol-2-yl)aniline (5) was purified as a white solid by silica gel column chromatography using ethyl acetate: hexane (4:1) as eluent. Yield: 82%; Melting point: 207-209 °C; 1H NMR (400 MHz, DMSO-d6): δ= 7.96 (d, 2H, J = 8.72 Hz, ArH), 7.55-7.51 (m, 2H, ArH), 7.16-7.14 (m, 2H, ArH), 6.75 (d, 2H, J = 8.24 Hz, ArH) , 4.45 (bs, 2H, NH2); 13C NMR (100 MHz, DMSO-d6): δ= 152.2,148.4,127.5,120.9,118.6,113.8 (ArC); MS (ESI), m/z: 210.2 (M++1).
References
[1] Chemical and Pharmaceutical Bulletin, 2007, vol. 55, # 1, p. 115 - 117
[2] Chinese Chemical Letters, 2011, vol. 22, # 3, p. 296 - 299
[3] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 24 - 35
[4] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 59 - 69
[5] Journal of the Chilean Chemical Society, 2012, vol. 57, # 2, p. 1122 - 1125,4
4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE Preparation Products And Raw materials
Raw materials
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