(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride
- Product Name
- (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride
- CAS No.
- 38176-02-2
- Chemical Name
- (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride
- Synonyms
- LU 33925;NSC 632821;CCRIS 2680;R-Verapamil HCl;Verapamil impurity 31;Dexverapamil monohydrochloride;R(+)-Verapamil monohydrochloride;R(+)-Verapamil monohydrochloride hydrate;R(+)-Verapamil hydrate monohydrochloride;R(+)-VERAPAMIL MONOHYDROCHLORIDE MONOHYDRATE
- CBNumber
- CB3931684
- Molecular Formula
- C27H41ClN2O5
- Formula Weight
- 509.07784
- MOL File
- 38176-02-2.mol
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Property
- Melting point:
- 129-131?C
- storage temp.
- Refrigerator
- solubility
- H2O: >30mg/mL
- form
- powder
- color
- white
- optical activity
- [α]22/D +9.6°, c = 0.5 in ethanol(lit.)
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25
- Safety Statements
- 22-36/37/39-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- V106
- Product name
- R(+)-Verapamil monohydrochloride hydrate
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $268
- Updated
- 2024/03/01
- Product number
- V106
- Product name
- R(+)-Verapamil monohydrochloride hydrate
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $1010
- Updated
- 2024/03/01
- Product number
- V124990
- Product name
- (R)-(+)-VerapamilHydrochloride
- Packaging
- 2mg
- Price
- $335
- Updated
- 2021/12/16
- Product number
- CS-0111666
- Product name
- (R)-Verapamil(hydrochloride)
- Purity
- 98.54%
- Packaging
- 10mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- ID28684
- Product name
- (2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride
- Packaging
- 2mg
- Price
- $578.1
- Updated
- 2021/12/16
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Chemical Properties,Usage,Production
Chemical Properties
Colourless solid
Uses
Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.
Uses
R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.
Definition
ChEBI: Dexverapamil hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of dexverapamil and hydrogen chloride. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil hydrochloride exhibits lower calcium antagonistic activity and toxicity than racemic verapamil hydrochloride. It has a role as an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor. It contains a dexverapamil(1+). It is an enantiomer of a (S)-verapamil hydrochloride.
Biochem/physiol Actions
Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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