GUANOXAN SULFATE
- Product Name
- GUANOXAN SULFATE
- CAS No.
- 5714-04-5
- Chemical Name
- GUANOXAN SULFATE
- Synonyms
- GUanoxani (sulfate);Guanoxan Hemisulfate;Guanoxan sulfate USP/EP/BP;(1,4-Benzodioxan-2-ylmethyl)guanidine sulfate;1-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)guanidine;1-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)Methyl)guanidine sulfate(2:1)
- CBNumber
- CB41011285
- Molecular Formula
- 2C10H13N3O2.H2O4S
- Formula Weight
- 512.541
- MOL File
- 5714-04-5.mol
GUANOXAN SULFATE Property
- Melting point:
- >200°C (dec.)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- G839500
- Product name
- GuanoxanHemisulfate
- Packaging
- 100mg
- Price
- $1455
- Updated
- 2021/12/16
- Product number
- FB41836
- Product name
- (1,4-Benzodioxan-2-ylmethyl)guanidine sulfate
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB41836
- Product name
- (1,4-Benzodioxan-2-ylmethyl)guanidine sulfate
- Packaging
- 25mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FB41836
- Product name
- (1,4-Benzodioxan-2-ylmethyl)guanidine sulfate
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- V1757
- Product name
- Guanoxansulfate
- Packaging
- 25mg
- Price
- $185
- Updated
- 2021/12/16
GUANOXAN SULFATE Chemical Properties,Usage,Production
Originator
Envacar,Pfizer
Uses
Antihypertensive.
Uses
Guanoxan is a sympatholytic drug related to Guanethidine (G815000). Guanoxan is used in the treatment of hypertension.
Manufacturing Process
2 Methods of producing of 2-guanidinemethyl-2,3-dihydro-1,4-benzodioxine:
1. 3.3 parts by weight of 2-aminomethyl-1,4-benzodioxane and 2.78 parts by
weight of S-methylisothiouronium sulfate were dissolved in 20 parts by
volume of water, and the resulting aqueous solution was heated under reflux
for 3 h. At the end of this time, the solvent was removed by means of
evaporation under reduced pressure and the residue so obtained dissolved in
a minimum amount of fresh water and treated with charcoal. Upon filtration,
there was obtained a clear filtrate which, on standing, soon afforded pure
crystals of di(2-guanidinomethyl-1,4-benzodioxane)sulfate, melting point
204°-205°C.
The base 2-guanidinemethyl-2,3-dihydro-1,4-benzodioxine may be obtained
by reaction of di(2-guanidinomethyl-1,4-benzodioxane)sulfate with, for
example, sodium hydroxide.
2. o-Dihydroxybenzene reacted with epichlorhydrine in the presence sodium
hydroxide and 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine was obtained.
To solution of 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine thionylchloride
was added to give 2-chlormethyl-2,3-dihydro-1,4-benzodioxine.
2-Chloromethyl-2,3-dihydro-1,4-benzodioxine reacted with benzylamine to
produced 2-benzylaminomethyl-2,3-dihydro-1,4-benzodioxine, which was
reduced at the presence of hydrogen and Pd-C (catalyst) to 2-aminomethyl-
2,3-dihydro-1,4-benzodioxine.
2-Aminomethyl-2,3-dihydro-1,4-benzodioxine was treated by Smethylisothiouronium sulfate and there was produced 2-guanidinemethyl-2,3-
dihydro-1,4-benzodioxine.
brand name
Envacar (Pfizer).
Therapeutic Function
Antihypertensive
GUANOXAN SULFATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GUANOXAN SULFATE manufacturers
- Product
- Guanoxan 5714-04-5
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-09