ChemicalBook > CAS DataBase List > Stamulumab
Stamulumab
- Product Name
- Stamulumab
- CAS No.
- 705287-60-1
- Chemical Name
- Stamulumab
- Synonyms
- Myo-029;Myo 029;STAMULUMAB;Research Grade Stamulumab;Research Grade Stamulumab (DHA30604)
- CBNumber
- CB41011755
- Formula Weight
- 0
- MOL File
- Mol file
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Stamulumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Stamulumab Chemical Properties,Usage,Production
Uses
Treatment of muscular dystrophy and age-related sarcopenia or frailty.
in vivo
Stamulumab (MYO-029; ip; 1-10 mg/kg/week for 12 weeks) increases skeletal muscle mass in vivo in a concentration-dependent manner in SCID mice. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia[1].
Stamulumab (i.v.; 1, 5, 20, 100 mg/kg/week for 4 weeks) has a central clearance (CL) of 0.25 mL/h/kg in C57/SCID mice[1].
Pharmacokinetic Parameters of Stamulumab (MYO-029)[1].
| C57/SCID mice IV (1-100 mg/kg/week for 4 weeks) | Sprague Dawley rats (2-50 mg/kg; single injection) | Cynomolgus monkeys (10-100 mg/kg/week for 5 or 39 weeks) | |
| CL (mL/h/kg) | 0.245 | 0.542 | 0.228 |
| Volume of central compartment (mL/kg) | 103 | 58.9 | 41.8 |
| Distributive clearance (mL/h/kg) | 1.79 | 0.815 |
| Animal Model: | Female SCID mice[1] |
| Dosage: | 1, 2.5, 5, 10 mg/kg |
| Administration: | IP; every week for 12 weeks |
| Result: | Increased skeletal muscle mass in vivo in a concentration‐dependent manner. |
Stamulumab Preparation Products And Raw materials
Raw materials
Preparation Products
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