Mofarotene

Product Name: Mofarotene
CAS No.: 125533-88-2
Chemical Name: Mofarotene
Synonyms: Mofarotene;4-[2-[4-[(E)-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]phenoxy]ethyl]morpholine
CBNumber: CB41179228
Molecular Formula: C29H39NO2
Formula Weight: 433.632
MOL File: 125533-88-2.mol

More

Less

Mofarotene Property

Melting point:: 107-109°

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

Mofarotene Chemical Properties,Usage,Production

Uses

Mofarotene (Ro 40-8757), an arotinoid, is anticancer compound. Mofarotene induces apoptosis, associated with mitochondrial membrane depolarization, activation of caspase-3 and -9, and enhanced production of reactive oxygen species. Mofarotene inhibits hematopoiesis in vitro by inhibiting maturation from primitive progenitor cells[1][2][3].

IC 50

Caspase 3; Caspase-9

References

[1] Valles B, et al. Metabolism of mofarotene in hepatocytes and liver microsomes from different species. Comparison with in vivo data and evaluation of the cytochrome P450 isoenzymes involved in human biotransformation. Drug Metab Dispos. 1995 Oct;23(10):1051-7. PMID:8654192
[2] Eliason JF, et al. Mofarotene (Ro 40-8757) inhibits hematopoiesis in vitro by preventing maturation from primitive progenitor cells. Blood. 1995 Dec 15;86(12):4516-26. PMID:8541541
[3] Cariati R, et al. Inhibition of oxidative phosphorylation underlies the antiproliferative and proapoptotic effects of mofarotene (Ro 40-8757) in Burkitt's lymphoma cells. Oncogene. 2003 Feb 13;22(6):906-18. DOI:10.1038/sj.onc.1206060

Mofarotene Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Mofarotene Suppliers

China 6 United States 1 Global 7

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

125533-88-2, MofaroteneRelated Search:

1-ISOPROPYL-4-(2-PHENYLVINYL)BENZENE Temarotene 4-TERT-BUTYLSTYRENE Mofarotene Trifarotene

4-[2-[4-[(E)-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]phenoxy]ethyl]morpholine

Mofarotene

125533-88-2

C29H39NO2