ChemicalBook > CAS DataBase List > 3-Deazauridine

3-Deazauridine

Product Name
3-Deazauridine
CAS No.
23205-42-7
Chemical Name
3-Deazauridine
Synonyms
NSC-126849;3-deazuridine;3-DEAZAURIDINE;3-DEAZAURIDINE CRYSTALLINE;3Deazauridine,3 Deazauridine;3-Deazauridine,anticancer antiviral;1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone;4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone;4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone;4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone
CBNumber
CB4125871
Molecular Formula
C10H13NO6
Formula Weight
243.21
MOL File
23205-42-7.mol
More
Less

3-Deazauridine Property

Melting point:
233-235°C
Boiling point:
569.2±50.0 °C(Predicted)
Density 
1.718±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
pka
4.50±1.00(Predicted)
color 
White to Pale Beige
InChI
InChI=1/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-3,6,8-10,12-13,15-16H,4H2/t6-,8-,9-,10-/s3
InChIKey
CBOKZNLSFMZJJA-FNMQVXAUNA-N
SMILES
[C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=CC(O)=CC1=O |&1:0,1,3,5,r|
LogP
-1.693 (est)
More
Less

Safety

RTECS 
UV1148000
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
23125
Product name
3-Deazauridine
Purity
≥98%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23125
Product name
3-Deazauridine
Purity
≥98%
Packaging
10mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
23125
Product name
3-Deazauridine
Purity
≥98%
Packaging
25mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
23125
Product name
3-Deazauridine
Purity
≥98%
Packaging
50mg
Price
$243
Updated
2024/03/01
Usbiological
Product number
007578
Product name
3-Deazauridine
Packaging
100mg
Price
$460
Updated
2021/12/16
More
Less

3-Deazauridine Chemical Properties,Usage,Production

Description

3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase, which is considered to be the primary mode of action of this nucleoside analog. This compound has been shown to possess in vitro activity against leukemia L1210 tumor cells, Ehrlich ascites tumor cells, Escherichia coli, and Streptococcus faecium. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with several antitumor agents, including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine. However, only the cytosine arabinoside/3-Deazauridine combination has been explored clinically[1-2].

Uses

Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.

Definition

ChEBI: 3-Deazauridine is a N-glycosyl compound.

References

[1] W J Moriconi, S Taylor, M Slavik. “3-Deazauridine (NSC 126849): an interesting modulator of biochemical response.” Investigational New Drugs 4 1 (1986): 67–84.
[2] W M Shannon, F M Schabel, G Arnett. “3-Deazauridine: inhibition of ribonucleic acid virus-induced cytopathogenic effects in vitro.” Antimicrobial Agents and Chemotherapy 2 3 (1972): 159–63.

3-Deazauridine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-Deazauridine Suppliers

Zhengzhou Granlen Sciences, ltd.
Tel
0371-85513397
Email
info@granlen.com
Country
China
ProdList
1827
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10269
Advantage
58
Zhengzhou GranLen pharmaceutical Technology Co., Ltd.
Tel
0371-85513397
Email
info@granlen.com
Country
China
ProdList
497
Advantage
55
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4619
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
132020
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15085
Advantage
58
Fuyang Ziyi Biological Pharmaceutical Co., Ltd.
Tel
19308655899
Fax
-
Email
2677609105@qq.com
Country
China
ProdList
449
Advantage
58
Nanjing crow LuNing pharmaceutical technology co., LTD
Tel
13382066392
Country
CHINA
ProdList
4880
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6870
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55477
Advantage
58
ROSEWA HOLDING GROUP CO.,LIMITED
Tel
+86-023-62871537
Email
sales@rosewachem.com
Country
China
ProdList
2830
Advantage
58
NewCan Biotech Limited
Tel
+86-571-86912261 +86-0571-86912261
Email
sales@newcanbio.com
Country
China
ProdList
10033
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 15093356674;
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30255
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
chenjw@absin.cn
Country
China
ProdList
24734
Advantage
58
Shanghai meikai technology co., ltd
Tel
021-18721550-091 18721550091
Fax
微信18721550091
Email
yangdong@pharma.com
Country
China
ProdList
4123
Advantage
58
Henan Weitesi Chemical Technology Co. LTD
Tel
0371-0371-55135753 18003832934
Fax
QQ:2853979818
Email
2853979818@qq.com
Country
China
ProdList
9991
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44499
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
39997
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Email
product02@bidepharm.com
Country
China
ProdList
61788
Advantage
58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
Tel
+86-027-59232304 15387063101
Email
2881924050@qq.com
Country
China
ProdList
9978
Advantage
58
Xi'an Kezhan Biotechnology Co., Ltd.
Tel
18729005399
Email
78282739@qq.com
Country
China
ProdList
2302
Advantage
58
Panaishen (Henan) Pharmaceutical Science and Technology Co. , Ltd.
Tel
0371-65325800 13700860222
Email
haifeng.zhang@pannacean.com
Country
China
ProdList
341
Advantage
58
Tangyuan Life Science (Shanghai) Co., Ltd
Tel
400-618-1121
Fax
400-618-1121
Email
sales@townyuan.com
Country
China
ProdList
2984
Advantage
58
Shaanxi Xihua Chemical Industry Co., Ltd
Tel
17691182729 15529505138
Email
1021@dideu.com
Country
China
ProdList
10011
Advantage
58
Shanghai Jianchao Biotechnology Co., LTD
Tel
86-1801738-3231 13621743886
Email
3366408901@qq.com
Country
China
ProdList
3820
Advantage
58
Shanghai Beiwanta Biotechnology Co., Ltd.
Tel
021-67187366 19901745723
Email
info@bwtlab.com
Country
China
ProdList
9240
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12007
Advantage
58
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD
Tel
0371-55159968 18137130222
Email
haifeng.zhang@pannacean.com
Country
China
ProdList
324
Advantage
58
Shenzhen Nexconn Pharmatechs Ltd
Tel
+86-755-89396905 +86-15013857715
Email
admin@nexconn.com
Country
China
ProdList
7836
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6846
Advantage
58
Shanghai Yubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
344843571@qq.com
Country
CHINA
ProdList
6322
Advantage
58
Shanghai Ziqi Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
2453006496@qq.com
Country
CHINA
ProdList
6192
Advantage
58
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6979
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6921
Advantage
58
Xiamen Research Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1562893815@qq.com
Country
CHINA
ProdList
6942
Advantage
58
Beijing Fubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
info@f-biology.com
Country
CHINA
ProdList
6039
Advantage
58

23205-42-7, 3-DeazauridineRelated Search:


  • 4-HYDROXY-1-BETA-D-RIBOFURANOSYL-2[1H]PYRIDONE
  • 3-DEAZAURIDINE
  • 3-deazuridine
  • 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinon
  • 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinone
  • 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridon
  • 3-DEAZAURIDINE CRYSTALLINE
  • 1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone
  • 4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone
  • 4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone
  • 4-Hydroxy-1-(β-D-ribofuranosyl)-1,2-dihydropyridin-2-one
  • 4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone
  • NSC-126849
  • 4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone
  • 1-[(2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-2-HYDROXYPYRIDIN-4-ONE
  • 2(1H)-Pyridinone, 4-hydroxy-1-β-D-ribofuranosyl-
  • 3-Deazauridine, 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, 3-DAU, NSC 126849
  • 2(1H)-Pyridinone,4-hydroxy-1-b-D-ribofuranosyl-
  • 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxypyridin-2(1H)-one
  • 3-Deazauridine,4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, synthetase inhibitor, anticancer drug, NSC126849, 3D2U
  • 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, NSC126849
  • 3Deazauridine,3 Deazauridine
  • 3-Deazauridine,anticancer antiviral
  • 23205-42-7
  • 232005-42-7
  • 20235-47-2
  • C10H13NO6
  • Bases & Related Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals