3-Deazauridine
- Product Name
- 3-Deazauridine
- CAS No.
- 23205-42-7
- Chemical Name
- 3-Deazauridine
- Synonyms
- NSC-126849;3-deazuridine;3-DEAZAURIDINE;3-DEAZAURIDINE CRYSTALLINE;3Deazauridine,3 Deazauridine;3-Deazauridine,anticancer antiviral;1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone;4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone;4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone;4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone
- CBNumber
- CB4125871
- Molecular Formula
- C10H13NO6
- Formula Weight
- 243.21
- MOL File
- 23205-42-7.mol
3-Deazauridine Property
- Melting point:
- 233-235°C
- Boiling point:
- 569.2±50.0 °C(Predicted)
- Density
- 1.718±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 4.50±1.00(Predicted)
- color
- White to Pale Beige
- InChI
- InChI=1/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-3,6,8-10,12-13,15-16H,4H2/t6-,8-,9-,10-/s3
- InChIKey
- CBOKZNLSFMZJJA-FNMQVXAUNA-N
- SMILES
- [C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=CC(O)=CC1=O |&1:0,1,3,5,r|
- LogP
- -1.693 (est)
Safety
- RTECS
- UV1148000
N-Bromosuccinimide Price
- Product number
- 23125
- Product name
- 3-Deazauridine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 23125
- Product name
- 3-Deazauridine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 23125
- Product name
- 3-Deazauridine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 23125
- Product name
- 3-Deazauridine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 007578
- Product name
- 3-Deazauridine
- Packaging
- 100mg
- Price
- $460
- Updated
- 2021/12/16
3-Deazauridine Chemical Properties,Usage,Production
Description
3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase, which is considered to be the primary mode of action of this nucleoside analog. This compound has been shown to possess in vitro activity against leukemia L1210 tumor cells, Ehrlich ascites tumor cells, Escherichia coli, and Streptococcus faecium. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with several antitumor agents, including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine. However, only the cytosine arabinoside/3-Deazauridine combination has been explored clinically[1-2].
Uses
Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.
Definition
ChEBI: 3-Deazauridine is a N-glycosyl compound.
References
[1] W J Moriconi, S Taylor, M Slavik. “3-Deazauridine (NSC 126849): an interesting modulator of biochemical response.” Investigational New Drugs 4 1 (1986): 67–84.
[2] W M Shannon, F M Schabel, G Arnett. “3-Deazauridine: inhibition of ribonucleic acid virus-induced cytopathogenic effects in vitro.” Antimicrobial Agents and Chemotherapy 2 3 (1972): 159–63.
3-Deazauridine Preparation Products And Raw materials
Raw materials
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