S-(2-thiopyridyl)mercaptopropionohydrazide

Product Name: S-(2-thiopyridyl)mercaptopropionohydrazide
CAS No.: 115616-51-8
Chemical Name: S-(2-thiopyridyl)mercaptopropionohydrazide
Synonyms: 3-(2-Pyridyldisulfanyl)propanehydrazide;3-(pyridin-2-yldisulfanyl)propanehydrazide;S-(2-thiopyridyl)mercaptopropionohydrazide;3-(2-Pyridyldithio)propionylhydrazide(PDPH);Propanoic acid, 3-(2-pyridinyldithio)-, hydrazide
CBNumber: CB41322297
Molecular Formula: C8H11N3OS2
Formula Weight: 229.32
MOL File: 115616-51-8.mol

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S-(2-thiopyridyl)mercaptopropionohydrazide Property

Melting point:: 87-90°C
Boiling point:: 463.6±41.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 12.81±0.35(Predicted)
color: White
Stability:: Light Sensitive

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 803480
Product name: PDPH (3-(2-pyridyldithio)propionyl hydrazide)
Packaging: 50MG
Price: $335
Updated: 2025/07/31

TRC

Product number: P993040
Product name: 3-(2-Pyridyldithio)propanoicAcidHydrazide
Packaging: 5mg
Price: $140
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0009632
Product name: 3-(2-PYRIDYLDITHIO)PROPANOIC ACID HYDRAZIDE
Purity: 95.00%
Packaging: 5MG
Price: $774.4
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0009632
Product name: 3-(2-PYRIDYLDITHIO)PROPANOIC ACID HYDRAZIDE
Purity: 95.00%
Packaging: 50MG
Price: $1871.1
Updated: 2021/12/16

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S-(2-thiopyridyl)mercaptopropionohydrazide Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A fluorescent sulfhydryl active reagent.

General Description

The PDPH is a heterobifunctional crosslinker containing sulfhydryl-reactive pyridyldithiol and carbonyl-reactive hydrazide moieties. Pyridyldithiols react with free sulfhydryls (-SH) to form disulfide bonds. Hydrazide groups react with carbonyls (aldehydes and ketones) to form stable hydrazone bonds. Aldehyde groups can be created by periodate-oxidation of sialic acid and other sugar components of glycoprotein polysaccharides. Thus, PDPH is useful for conjugating glycoproteins and sulfhydryl-containing peptides or proteins. Likewise, PDPH is useful as a sulfhydryl-addition reagent for glycoproteins and other carbohydrates; after reaction of the hydrazide to an oxidized carbohydrate, the pyridyldithiol group can be cleaved by a reducing agent to expose a sulfhydryl group. Yet another application for PDPH is to react the primary amine of the hydrazide moiety to a carboxyl group using the crosslinker EDC.

reaction suitability

reagent type: cross-linking reagent

S-(2-thiopyridyl)mercaptopropionohydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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S-(2-thiopyridyl)mercaptopropionohydrazide Suppliers

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S-(2-thiopyridyl)mercaptopropionohydrazide

3-(2-Pyridyldithio)propionylhydrazide(PDPH)

Propanoic acid, 3-(2-pyridinyldithio)-, hydrazide

3-(pyridin-2-yldisulfanyl)propanehydrazide

3-(2-Pyridyldisulfanyl)propanehydrazide

115616-51-8

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