UK 1
- Product Name
- UK 1
- CAS No.
- 151271-53-3
- Chemical Name
- UK 1
- Synonyms
- UK 1;UK 1 (cytotoxin);2'-(2-Hydroxyphenyl)-[2,4'-bibenzoxazole]-4-carboxylic acid methyl ester;[2,4'-Bibenzoxazole]-4-carboxylic acid, 2'-(2-hydroxyphenyl)-, methyl ester
- CBNumber
- CB41370041
- Molecular Formula
- C22H14N2O5
- Formula Weight
- 386.36
- MOL File
- 151271-53-3.mol
UK 1 Property
- Melting point:
- 209-210℃
- Boiling point:
- 541.4±30.0 °C(Predicted)
- Density
- 1.396±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO;Soluble in dimethyl formamide
- form
- solid
- pka
- 8.55±0.30(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20139
- Product name
- UK 1
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $279
- Updated
- 2024/03/01
- Product number
- 20139
- Product name
- UK 1
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $1182
- Updated
- 2024/03/01
- Product number
- 207430
- Product name
- UK-1
- Packaging
- 250ug
- Price
- $316
- Updated
- 2021/12/16
- Product number
- U700623
- Product name
- UK-1
- Packaging
- 250μg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- U0884-01
- Product name
- UK-1
- Packaging
- 1mg
- Price
- $513
- Updated
- 2021/12/16
UK 1 Chemical Properties,Usage,Production
Uses
UK-1 is an antibiotic and antifungal inhibitor of topoisomerase II.
Uses
UK-1 is an unusual bis-benzoxazole metabolite isolated from a species of Streptomyces. UK-1 exhibits good antitumour activity but is devoid of antimicrobial activity. UK-1 acts as a magnesium ion-dependent, DNA binding agent and inhibitor of human topoisomerase II.
Biological Activity
uk 1, an unusual bis-benzoxazole metabolite isolated from streptomyces sp. 517-02, is an inhibitor of topoisomerase ii (topo ii) and hepatitis c viral replication. it is an antifungal and an antibiotic, and displays a wide spectrum of potent anticancer activities against lymphoma, leukemia, and certain solid tumor-derived cell lines with ic50 values as low as 20 nm. however, uk 1 is devoid of antimicrobial activity and is inactive against pseudomonas aeruginosa and staphylococcus aureus, a methicillin-resistant strain of s. aureus. additionally, uk-1 can bind a wide variety of di- and tri-valent metal ions, particularly mg2+ ions, and form complexes with dna in the presence of mg2+ ions. topo ii are atp-dependent enzymes, which can simultaneously cut both strands of the dna helix to manage dna supercoils and tangles.
in vitro
uk 1 strongly blocked the growth of human epitheloid carcinoma hela, mouse melanoma b16, mouse leukemia p388 cells with ed50 values of 1.22 μg/ml, 1.17 μg/ml, and 0.11 μg/ml, respectively. uk 1 did not display any growth inhibitory activity against bacteria, fungi and yeasts up to 100 μg/ml [1].
storage
+4°C
References
[1]. ueki, m., ueno, k., miyadoh, s., abe, k., shibata, k., taniguchi, m., & oi, s. uk-1, a novel cytotoxic metabolite from streptomyces sp. 517-02. i. taxonomy, fermentation, isolation, physico-chemical and biological properties. the journal of antibiotics. 1993; 46(7): 1089-1094.
UK 1 Preparation Products And Raw materials
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