ChemicalBook > CAS DataBase List > UK 1

UK 1

Product Name
UK 1
CAS No.
151271-53-3
Chemical Name
UK 1
Synonyms
UK 1;UK 1 (cytotoxin);2'-(2-Hydroxyphenyl)-[2,4'-bibenzoxazole]-4-carboxylic acid methyl ester;[2,4'-Bibenzoxazole]-4-carboxylic acid, 2'-(2-hydroxyphenyl)-, methyl ester
CBNumber
CB41370041
Molecular Formula
C22H14N2O5
Formula Weight
386.36
MOL File
151271-53-3.mol
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UK 1 Property

Melting point:
209-210℃
Boiling point:
541.4±30.0 °C(Predicted)
Density 
1.396±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO;Soluble in dimethyl formamide
form 
solid
pka
8.55±0.30(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20139
Product name
UK 1
Purity
≥95%
Packaging
1mg
Price
$279
Updated
2024/03/01
Cayman Chemical
Product number
20139
Product name
UK 1
Purity
≥95%
Packaging
5mg
Price
$1182
Updated
2024/03/01
Usbiological
Product number
207430
Product name
UK-1
Packaging
250ug
Price
$316
Updated
2021/12/16
TRC
Product number
U700623
Product name
UK-1
Packaging
250μg
Price
$110
Updated
2021/12/16
Usbiological
Product number
U0884-01
Product name
UK-1
Packaging
1mg
Price
$513
Updated
2021/12/16
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UK 1 Chemical Properties,Usage,Production

Uses

UK-1 is an antibiotic and antifungal inhibitor of topoisomerase II.

Uses

UK-1 is an unusual bis-benzoxazole metabolite isolated from a species of Streptomyces. UK-1 exhibits good antitumour activity but is devoid of antimicrobial activity. UK-1 acts as a magnesium ion-dependent, DNA binding agent and inhibitor of human topoisomerase II.

Biological Activity

uk 1, an unusual bis-benzoxazole metabolite isolated from streptomyces sp. 517-02, is an inhibitor of topoisomerase ii (topo ii) and hepatitis c viral replication. it is an antifungal and an antibiotic, and displays a wide spectrum of potent anticancer activities against lymphoma, leukemia, and certain solid tumor-derived cell lines with ic50 values as low as 20 nm. however, uk 1 is devoid of antimicrobial activity and is inactive against pseudomonas aeruginosa and staphylococcus aureus, a methicillin-resistant strain of s. aureus. additionally, uk-1 can bind a wide variety of di- and tri-valent metal ions, particularly mg2+ ions, and form complexes with dna in the presence of mg2+ ions. topo ii are atp-dependent enzymes, which can simultaneously cut both strands of the dna helix to manage dna supercoils and tangles.

in vitro

uk 1 strongly blocked the growth of human epitheloid carcinoma hela, mouse melanoma b16, mouse leukemia p388 cells with ed50 values of 1.22 μg/ml, 1.17 μg/ml, and 0.11 μg/ml, respectively. uk 1 did not display any growth inhibitory activity against bacteria, fungi and yeasts up to 100 μg/ml [1].

storage

+4°C

References

[1]. ueki, m., ueno, k., miyadoh, s., abe, k., shibata, k., taniguchi, m., & oi, s. uk-1, a novel cytotoxic metabolite from streptomyces sp. 517-02. i. taxonomy, fermentation, isolation, physico-chemical and biological properties. the journal of antibiotics. 1993; 46(7): 1089-1094.

UK 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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151271-53-3, UK 1Related Search:


  • UK 1
  • UK 1 (cytotoxin)
  • 2'-(2-Hydroxyphenyl)-[2,4'-bibenzoxazole]-4-carboxylic acid methyl ester
  • [2,4'-Bibenzoxazole]-4-carboxylic acid, 2'-(2-hydroxyphenyl)-, methyl ester
  • 151271-53-3