4-Amino-3,5-dichloropyridine N-oxide
Preparation- Product Name
- 4-Amino-3,5-dichloropyridine N-oxide
- CAS No.
- 91872-02-5
- Chemical Name
- 4-Amino-3,5-dichloropyridine N-oxide
- Synonyms
- Roflumilast Impurity 17;4-Amino-3,5-dichloropyridine N-oxide;3,5-dichloro-4-aminopyridine 1-oxide;4-Pyridinamine, 3,5-dichloro-, 1-oxide
- CBNumber
- CB41501469
- Molecular Formula
- C5H4Cl2N2O
- Formula Weight
- 179
- MOL File
- 91872-02-5.mol
4-Amino-3,5-dichloropyridine N-oxide Property
- Melting point:
- 210 °C (decomp)
- Boiling point:
- 391.6±37.0 °C(Predicted)
- Density
- 1.66±0.1 g/cm3(Predicted)
- pka
- 2.25±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- A632005
- Product name
- 4-Amino-3,5-dichloropyridineN-Oxide
- Packaging
- 10mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- HCH0358694
- Product name
- 4-AMINO-3,5-DICHLOROPYRIDIN-1-IUM-1-OLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.21
- Updated
- 2021/12/16
4-Amino-3,5-dichloropyridine N-oxide Chemical Properties,Usage,Production
Preparation
4-amino-3,5-dichloropyridine-N-oxide is prepared by the following steps:A sealed Carius tube containing 4-nitro-3,5-dichloropyridine-N-oxide (36) (0.4 g, 1.9 mmol), aqueous ammonia (1 cm3 of 0.88 gi-l solution) and acetonitrile (1 cm3) was heated in a rotating oil bath at 70 OC for 3 h. The mixture was filtered giving a solid (0.1 g) and a filtrate, which was extracted into DCM, dried (MgS04) and evaporated giving a residue (0.0 g). The solid obtained from the filtration was recrystallised from hot methanol giving 4-amino-3,5-dichloropyridine-N-oxide (0.1 g, 30%), m.p. 210 oC from MeOH) (M+ found 177.9701. C5H4Cl2N20 requires M+ 177.9701); IR spectra no. 30; mass spectra no. 37; nmr spectrum no. 45.
Uses
4-Amino-3,5-dichloropyridine N-Oxide is the impurity of the drug Roflumilast (R639700), which is a selective phosphodiesterase 4(PDE4) inhibitor, antiasthmatic.
4-Amino-3,5-dichloropyridine N-oxide Preparation Products And Raw materials
Raw materials
Preparation Products
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