5,7-Diaza-spiro[3.4]octane-6,8-dione

Product Name: 5,7-Diaza-spiro[3.4]octane-6,8-dione
CAS No.: 89691-88-3
Chemical Name: 5,7-Diaza-spiro[3.4]octane-6,8-dione
Synonyms: NSC 51773;5,7-Diaza-spiro[3.4]octane-6,8-dione;5,7-Diaza-Spiro[3.4]Octane-6,8-Dione(WX619040)
CBNumber: CB41508514
Molecular Formula: C6H8N2O2
Formula Weight: 140.14
MOL File: 89691-88-3.mol

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5,7-Diaza-spiro[3.4]octane-6,8-dione Property

Melting point:: 224 - 225°C
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 10.46±0.20(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D679808
Product name: 5,7-Diazaspiro[3.4]octane-6,8-dione
Packaging: 10mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 5980BA
Product name: 5,7-Diazaspiro[3.4]octane-6,8-dione
Packaging: 250mg
Price: $169
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0121622
Product name: 5,7-DIAZASPIRO[3.4]OCTANE-6,8-DIONE
Purity: 95.00%
Packaging: 1G
Price: $1611.23
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0121622
Product name: 5,7-DIAZASPIRO[3.4]OCTANE-6,8-DIONE
Purity: 95.00%
Packaging: 5G
Price: $3632.48
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0121622
Product name: 5,7-DIAZASPIRO[3.4]OCTANE-6,8-DIONE
Purity: 95.00%
Packaging: 10G
Price: $5364.98
Updated: 2021/12/16

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5,7-Diaza-spiro[3.4]octane-6,8-dione Chemical Properties,Usage,Production

Synthesis

773837-37-9

1191-95-3

506-87-6

89691-88-3

34 General procedure for the synthesis of 5,7-diazaspiro[3.4]octane-6,8-dione from the compound (CAS: 773837-37-9), cyclobutanone and ammonium carbonate: 34.1 Sodium cyanide (1.47 g, 30 mmol) and ammonium carbonate (7.5 g, 78 mmol) were added to the reaction flask under argon protection. Subsequently, a mixed ethanol-water solvent (16 mL) solution of cyclobutanone (1.49 mL, 20 mmol) was added to the reaction system at 23°C. The reaction mixture was heated to 70 °C with continuous stirring for 6 hours. Upon completion of the reaction, the reaction mixture was cooled, poured into water (15 mL), and then concentrated hydrochloric acid (13 mL) solution was slowly added. Stirring was continued at 23 °C for 10 hours. After that, ethanol and some water were removed from the reaction mixture using a rotary evaporator. The precipitate was filtered through a glass filter and washed with distilled water. The target compound 5,7-diazaspiro[3.4]octane-6,8-dione was finally obtained as a beige powder in 39% yield (1.1 g). 1H NMR (400 MHz, DMSO-d6) δ: 10.49 (s, 1H, NH), 8.27 (s, 1H, NH), 2.31-2.37 (m, 2H, CH2), 2.19-2.27 (m, 2H, CH2), 1.83-1.90 (m, 1H, CHA), 1.71-1.76 (m, 1H, CHB ). Melting point: 223-225°C.

References

[1] Patent: US2012/83514, 2012, A1. Location in patent: Page/Page column 19

5,7-Diaza-spiro[3.4]octane-6,8-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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5,7-Diaza-spiro[3.4]octane-6,8-dione Suppliers

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89691-88-3, 5,7-Diaza-spiro[3.4]octane-6,8-dione Related Search:

3-(6,8-dioxo-5,7-diazaspiro[3.4]oct-7-yl)propanoic acid (6,8-dioxo-5,7-diazaspiro[3.4]oct-7-yl)acetonitrile ethyl (6,8-dioxo-5,7-diazaspiro[3.4]oct-7-yl)acetate 5,7-Diaza-spiro[3.4]octane-6,8-dione (6,8-dioxo-5,7-diazaspiro[3.4]oct-7-yl)acetic acid

NSC 51773

5,7-Diaza-Spiro[3.4]Octane-6,8-Dione(WX619040)

5,7-Diaza-spiro[3.4]octane-6,8-dione

89691-88-3